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赵美霞
2017-03-06 18:33   审核人:


赵美霞,女,博士,校特聘教授,博士生导师,河南省高校科技创新人才,河南省教育厅学术技术带头人,河南省高等学校青年骨干教师,美国华盛顿大学(University of Washington)国家公派访问学者,广东省优秀博士学位论文获得者,先后在BiomaterialsChemistry-A European JournalJournal of Materials ChemistryChemistry-An Asian Journal等杂志上发表论文20余篇,授权国家发明专利3项。主持国家自然科学基金2项,主持国家留学基金项目1项,主持省级项目5项。获得河南第三届自然科学学术奖一等奖和三等奖。

教育经历:

2005.9-2007.7 暨南大学 生命科学技术学院化学系 硕士

2008.9-2011.7 中山大学 化学与化学工程学院 博士

工作经历:

2011.9—至今 河南大学 天然药物与免疫工程重点实验室 副教授

2016.3—2017. 3 美国华盛顿大学(University of Washington)国家公派访学

研究方向:1.量子点纳米药物载体及荧光探针的合成及性质研究

2.抗肿瘤药物的设计合成及其抗肿瘤活性研究

联系方式:zhaomeixia2011@henu.edu.cn;zhaomeixia11@126.com

学术成果:

一、论文

1.M-X Zhao,*B-J Zhu,W-J Yao, D-F Chen.Therapeutic effect of quantum dots for cancer treatment.RSC Adv. 2016,6, 113791-113795.

2.M-X Zhao*, B-J Zhu. The research and applications of quantum dots nano-drug carriers in biological fields.Nanoscale Res. Lett.2016, 22, 207.

3.M-X Zhao*, E-Z Zeng. Application of functional quantum dot nanoparticles as fluorescence probes in cell labeling and tumor diagnostic imaging.Nanoscale Res. Lett.2015, 10,171.

4.Mei-Xia Zhao,* Er-Zao Zeng, Bing-Jie Zhu. The biological applications of inorganic nanoparticle drug carriers.ChemNanoMat,2015, 1, 82-91.

5.XLiu, H-LLiu*, NFang, X-MLi, W-HGuo*, Wu J-H,M-X Zhao*. Facile synthesis of multifunctional La1xSrxMnO3@Au core-shell nanoparticles for biomedical applications.RSC Adv.2015, 5, 95454-95462.

6.M-X Zhao*, E-Z Zeng, Y Li, C-J Wang*. A study on effects of naphthalimide derivativecapped quantum dots on the cellular internalization, proliferation, and apoptosis ability.J. Mater. Chem. B2014, 2, 7351-7359.

7.M-X Zhao*, Y Li, E-Z Zeng, C-J Wang*. The application of CdSe quantum dots with multicolor emission as fluorescent probes for cell labeling.Chem. Asian J.2014, 9, 1349-1355. (封底文章)

8.M-X Zhao, M Zhao, E-Z Zeng, Y Li, J-M Li, Q Cao, C-P Tan, L-N Ji, Z-W Mao*. Enhanced anti-cancer efficacy to cancer cells by doxorubicin loaded water-soluble amino acid-modifiedβ-cyclodextrin platinum complexes.J. Inorg. Biochem.2014, 137, 31-39.

9.M-X Zhao,*Y Li, C Wang. Synthesis and bioactivity of the folate receptor targeted γ-cyclodextrin-folate inclusion-coated CdSe/ZnS quantum dots.Acta Pharmaceutica Sinica2013, 48, 566-572.

10.M-X Zhao, L-N Ji, Z-W Mao*.b-Cyclodextrin/glycyrrhizic acid-functionalized quantum dots selectively enter hepatocarcinoma and induce apoptosis.Chem. Eur. J.2012, 18, 1650-1658.

11.M-XZhao,HSu, Z-W Mao*, L-N Ji. Synthesis, biocompatibility and luminescence properties ofquantum dots conjugated with amino acid-functionalizedb-cyclodextrin.J. Lumin.2012, 132, 16-22.

12.J-M Li, Y-Y Wang,M-X Zhao, C-P Tan, Y-Q Li, X-Y Le, L-N Ji, Z-W Mao*. Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking.Biomaterials2012, 33, 2780-2790.

13.M-X Zhao, H-F Huang, Q Xia*, L-N Ji, Z-W Mao*.g-Cyclodextrin/folatecomplex-functionalized quantum dots for tumor-targeting and site-specific labeling.J. Mater. Chem.2011, 21, 10290-10297. (封底文章,热点文章)

14.M-X Zhao, J-M Li, L Du, C-P Tan, Q Xia*, Z-W Mao*, L-N Ji. Targeted cellular uptake and siRNA silencing by quantum dots nanoparticles coated withb-cyclodextrin coupled to amino acid.Chem. Eur. J.2011, 17, 5171-5179. (封面文章)

15.J-M Li,M-X Zhao, H Su, Y-Y Wang, C-P Tan, L-N Ji, Z-W Mao*. Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging.Biomaterials2011, 32, 7978-7987.

16.M-X Zhao, Q Xia*, X-D Feng, X-H Zhu, Z-W Mao*, L-N Ji, K Wang. Synthesis, biocompatibility and cell labeling of L-arginine-functionalb-cyclodextrin-modified quantum dot probes.Biomaterials2010, 31, 4401-4408.

二、专利:

1.赵美霞,王超杰,李洋.一种萘酰亚胺-氨基酸化合物及其修饰的量子点的制备、应用,中国授权发明专利,授权号: ZL 2013 1 0691278.3,授权日:2015.5

2.赵美霞,王超杰,甘莹,李景华,李洋,曾二造.一种氨基酸-胺缀合物及其制备方法和应用.中国授权发明专利,授权号:ZL 2014 1 0074636.0,授权日:2016.7

3.毛宗万,赵美霞,黄华珍,计亮年.一种肿瘤靶向性的功能化量子点及其制备方法.中国发明专利,公布号:CN 101806795 A,公布日:2010.8

三、项目

1)多胺衍生物功能化的量子点靶向纳米药物的合成及其诱导细胞凋亡的机制研究.国家自然科学基金.(21501044), 2016.1.-2018.12.主持

2)“多胺-环糊精-量子点”纳米药物转运系统的设计及生物活性研究.国家自然科学基金(No U1204201), 2013.01-2015.12,主持

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