程建军

 

程建军,男,199012月,博士,副教授(校聘),河南大学,天然药物与免疫工程重点实验室,石家华教授团队。

一、 教育经历

2017.09-2021.12 哈尔滨工业大学,化学工程与技术,工学博士

2014.09-2017.07 哈尔滨师范大学,有机化学,理学硕士(推免)

2010.09-2014.07 哈尔滨师范大学,制药工程,理学学士

二、 工作经历

2022.02-至今,河南大学,天然药物与免疫工程重点实验室,副教授(校聘)

三、 研究方向及兴趣

自组装天然功能小分子载药系统研究(化疗/光疗/免疫治疗)

四、 学术成果

学术论文:

1) Cheng, J.J., Zhao, H.T., Li, B., Zhang, H., Shi, J.H., Yang, X*, et al., Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy. Acta. Pharm. Sin. B. 2022, Revision (中科院一区, IF:11.614)

2) Cheng, J.J., Li, X.Y., Wang, S., Han, Y., Zhao, H.T., and Yang, X*. Carrier-free triterpene prodrugs with glutathione response and biosafety for synergistically enhanced photochemotherapy. ACS Appl. Mater. Interfaces. 2021, 13, 245-256. (中科院一区, IF:9.229)

3) Cheng, J.J., Wang, S., Zhao, H.T., Liu, Y., and Yang, X*. Exploring self-assembly mechanism and effective synergistic antitumor chemophototherapy of biodegradable and glutathione responsive ursolic acid prodrug mediated photosensitive nanodrug. Biomater. Sci., 2021, 9, 3762-3775. (中科院IF:6.843)

4) Cheng, J.J., Fu, S.Y., Qin, Z., Han, Y., and Yang, X*. Self-assembled natural small molecule diterpene acids with favorable anticancer activity and biosafety for synergistically enhanced antitumor chemotherapy. J. Mater. Chem. B, 2021, 9, 2674-2687. (中科院, IF:6.331)

5) 程建军,杨鑫*.三萜天然小分子自组装机制及其协同抗癌应用研究.药学学报, 2021, 56, 2102-2111.

6) Cheng, J.J., Zhao, H.T., Wang, J.C., Han, Y., and Yang, X*. Bioactive natural small molecule-tuned coassembly of photosensitive drugs for highly efficient synergistic and enhanced type i photochemotherapy. ACS Appl. Mater. Interfaces. 2020, 12, 43488-43500. (中科院一区, IF:9.229)

7) Cheng, J.J., Zhao, H.T., Yao, L., Li, Y., * Qi, B.K., Wang, J., and Yang, X*. Simple and multifunctional natural self-assembled sterols with anticancer activity-mediated supramolecular photosensitizers for enhanced antitumor photodynamic therapy. ACS Appl. Mater. Interfaces. 2019, 11, 29498-29511. (中科院一区, IF:9.229)

8) Cheng, J.J., Li W.T., Tan, G.H., Wang, Z.Q., Li, S.Y., Jin, Y.X. *, Synthesis and in vitro photodynamic therapy of chlorin derivative 131-ortho-trifluoromethyl-phenylhydrazone modified pyropheophorbide-a. Biomed. Pharmacother. 2017, 87, 263–273. (中科院, IF:6.529)

9) Zhang, H.Y#., Cheng, J.J#., Li W.T., Tan, G.H., Wang, Z.Q., Jin, Y.X*. Facile synthesis of a highly water-soluble graphene conjugated chlorophyll-a photosensitizer composite for improved photodynamic therapy in vitro. New. J. Chem., 2017, 41, 10069-10082. (中科院三区, IF:3.591)

10) Cheng, J.J., Tan, G.H., Li W.T., Zhang, H.Y., Wu, X.D., Wang, Z.Q., Jin, Y.X*. Facile synthesis of chitosan assisted multifunctional magnetic Fe3O4@SiO2@CS@pyropheophorbide-a fluorescent nanoparticles for photodynamic therapy. New. J. Chem., 2016, 40, 8522-8534. (中科院三区, IF:3.591)

11) Cheng, J.J., Tan, G.H., Li W.T., Li, J.H., Wang, Z.Q., Jin, Y.X*. Preparation, characterization and in vitro photodynamic therapy of a pyropheophorbide-a-conjugated Fe3O4 multifunctional magnetofluorescence photosensitizer. RSC Adv. 2016, 6, 37610-37620. (中科院三区, IF:3.361)

12) Li W.T#., Tan, G.H#., Cheng, J.J#., Wang, Z.Q., Jin, Y.X*. A novel photosensitizer 31,131-phenylhydrazine -Mppa (BPHM) and its in vitro photodynamic therapy against HeLa cells. Molecules 2016, 21, 558. (中科院, IF:4.411)

专利:

1) 杨鑫, 程建军. 一种活性天然超分子光敏剂的制备方法及其应用. 专利授权号: ZL 201910300795.0.

2) 杨鑫, 程建军, 赵海田. 一种活性天然小分子介导的共组装光敏药物的制备方法及应用. 专利申请号: CN202010414305.2.

3) 杨鑫, 程建军, 刘秀. 一种壳寡糖修饰的白桦脂酸药物运输体系的制备方法及其应用. 专利申请号: CN202010569071.9.

4) 杨鑫, 程建军, 王舒, 李欣瑜. 一种萜类小分子组装的氧化还原响应光敏药物的制备方法. 专利申请号: CN202010496822.9.

五、 参与研究项目

1)国家自然科学基金面上项目(31972040)松塔松香烷型三环二萜酸纳米自组装体的形成机理及其提高姜黄素体内生物利用度的研究, 2020-01-012023-12-31参与

六、 联系方式

邮箱chengjj@henu.edu.cn or chengjj667788@163.com

地址:河南省开封市河南大学金明校区

 

欢迎具有有机合成、天然药物化学、生物医学工程等专业背景的优秀学生加盟我们温馨、科研氛围浓郁的大家庭(或联系石家华教授:sjiahua@henu.edu.cn),携手并进。