王建红

王建红,男,1971年11月出生,博士,教授、博士生导师。目前在河南大学/河南省天然药物与免疫工程重点实验室从事科研、教学工作。主要研究方向为药物化学及疾病检测小分子探针的设计与评价。2010年获得河南省科学技术进步奖二等奖1项(第三名);2013年、2015年分别获得“河南省自然科学学术奖-优秀论文奖”一等奖各1项;并于2010年、2011年分别入选“河南大学青年骨干教师”和“河南省青年骨干教师”;2016年被评为“河南省教育厅学术技术带头人”;2016年入选“河南省高校科技创新人才计划”。任职以来已在国际专业期刊Expert Opinion on Drug DeliveryCurrent Medicinal ChemistrySensors and Actuators B:Chemistry等发表SCI论文30篇;已获国家知识产权局的发明专利授权4项。兼任的学术兼职:教育部学位与研究生教育发展中心通讯评议专家、河北省科技奖励评审专家、浙江省自然科学基金评审专家,同时担任Chem.Comm.;Med.Chem.Res.;Chem.Biology & Drug Design等专业性国际学术刊物的同行评审。

在研项目

1.河南省高校科技创新人才支持计划,16HASTIT029,基于化学反应基于化学反应的“双核”型荧光探针及其可视化检测细胞内生物活性分子,2016/01-2017/12,60万元,在研,主持。

近五年论文

(1)Jiamin Wang, Xiangmin Shao,Jianhong Wang(*), Shijun Shao(*), An NBD-based fluorescent turn-on probe for the detection of homocysteine over cysteine and its imaging applications, Chemistry Letters, 2017, 46 (4): 442-445.

(2)Xufeng Hou, Xinling Guo, Bing Chen, Chunhui Liu, Fan Gao,Jin Zhao(*),Jianghong Wang(*),Rhodamine-based fluorescent probe for highly selective detection ofglutathione over cysteine and homocysteine,Sensors and Actuators B: Chemical,2015,209:838–845.

(3) Xufeng Hou, Xinling Guo, Zhaoyang Luo, Huijun Zhao, Bing Chen, Jin Zhao(*),Jianhong Wang(*),A rhodamine-formaldehyde probe fluorescentlydiscriminates H2S from biothiols,AnalyticalMethods, 2014, 6(10):3223-3226.

(4)Jianhong Wang(*),Xinling Guo,Xufeng Hou,Huijun Zhao,Zhaoyang Luo,Jin Zhao.A Coumarin-basedfluorescentsensor forselectivedetection ofcopper (II),Bulletin of theKorean ChemicalSociety, 2014, 35(8): 2400-2402.

(5)JianhongWang(*),Huijun Zhao, Zhaoyang Luo, Zhaoyi Wang, Yahong Zhang, Jin Zhao(*).Synthesis andbologicalactivity ofanthrapyrazolesderivatives aspotentialantitumoragents,Medicinal Chemistry, 2014, 10(8): 772-777.

(6)Jianhong Wang(*), Tianwei Luo, Shaobin Li,Jin Zhao, The powerful applications of polyunsatured fatty acids in improving the therapeutic efficacy of anticancer drugs,Expert Opinion on Drug Delivery,2012, 9(1):1-7.

(7)Ying Gan, Lihua He, Yahong Zhang,Jianhong Wang(*), Jin Zhao(*),Synthesis and biological activity of anthraquinone-polyamine derivatives,ChineseJournal ofOrganicChemistry,2014, 34(3):589-595.

(7)Jianhong Wang(#),Pengfei Cheng, Tianwei Luo, Zhaoyi Wang, Yahong Zhang(*),Jin Zhao(*),Synthesis andpreliminarybiologicalevaluation ofpolyamine-anilineacridines as P-glycoproteininhibitors,Medicinal Chemistry, 2014, 10(5):506-511.

(8)Jianhong Wang(#),Ying Gan, Shaobin Li,Tianwei Luo, Yahong Zhang,Jin Zhao(*),Potent P-glycoprotein inhibition ofemodin derivative: synthesis and biologicalevaluation, Medicinal Chemistry Research, 2014, 23 (4): 2106-2112.

(9)Jianhong Wang(#),Tianwei Luo,Shaobin Li,Yahong Zhang,Chaojie Wang,Jin Zhao(*), Synthesis, structure-activity relationship and biological activity of acridine derivatives as potent MDR-reverseing agents, Current Medicinal Chemistry, 2013, 20 (32): 4070-4079.

(10)JianhongWang(#),Shaobin Li; Tianwei Luo; Chaojie Wang, Jin Zhao(*),Disulfide linkage: A potent strategy in tumor-targeting drug discovery,Current Medicinal Chemistry,2012, 19(18):2976-2983.

(11)JianhongWang(#),Ruihong Gao, Qian Li, Songqiang Xie,Jin Zhao(*), Chaojie Wang(*),Synthesis,cytotoxicity andcelldeathprofile ofpolyaminoanthraquinone asantitumoragents,Chemical Biology & Drug Design,2012, 80(6):909-917.

授权专利:

1.王建红,侯旭峰,要冲,张树峰,甘莹,赵瑾,一种具有半花菁-萘酰亚胺结构的化合物、其制备方法及应用,2016.11.30,中国,ZL201510390036.X

2.王建红,陈冰,高凡,齐建国,张树峰,董海洋,一种具有肿瘤响应性释放药物的化合物或其要用盐及其制备、应用,2017.07.06,中国,ZL201410769419.3

3.王建红,张亚宏,白淑霞,赵瑾,罗田伟,吖啶衍生物及其制备方法和应用,2013.11.8,中国,ZL201210209322.8

成果奖励:

1.Jianhong Wang(1/6),Synthesis, structure-activity relationship and biological activity of acridine derivatives as potent MDR-reverseing agents,河南省科学技术协会,河南省自然科学优秀学术论文,一等奖,2015.

(Jianhong Wang,Tianwei Luo, Shaobin Li, Yahong Zhang, Chaojie Wang, Jin Zhao)

2.Jianhong Wang(1/4),The powerful applications of polyunsaturated fatty acids in improving the therapeutic efficacyofanticancer drugs,河南省科学技术协会,河南省自然科学优秀学术论文,一等奖,2013.

(Jianhong Wang,Tianwei Luo, Shaobin Li, Jin Zhao)