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于树玲

姓名:于树玲

性别:女

出生日期:1984.12.10 专业:药物化学

所属课题组:石家华课题组

联系方式:yushuling@henu.edu.cn


个人基本信息:

博士,副教授


教育经历:

2010/09-2013/09,南京大学,化学化工学院,博士

2007/09-2010/06,常州大学,化学化工学院,硕士

2003/09-2007/06,洛阳师范学院,化学化工学院,学士


工作经历:2013/07至今,河南大学,河南省天然药物与免疫工程重点实验室,副教授


研究方向:基于环糊精纳米材料的构筑及药物输送方面的应用;有机-无机杂化纳米材料的设计、制备及药物输送方面的应用;计算机辅助药物合理设计。


学术成果:

1、论文

 1. Yi Zhang#, Shuxin Jia#, Jintao Yuan, Peide Zhu, Ying Gan, Guangfang Fan , Shuling Yu*, Jiahua Shi*, Porphyrin-Terminated Nanoscale Fluorescent Polyrotaxane as a Biodegradable Drug Carrier for Anticancer Research, Nanotechnology, 2020, 31, 255101.

 2. Yi Zhang#, Qiaoqiao Zhou#, Shuxin Jia, Kunpeng Lin, Guangfang Fan, Jintao Yuan, Shuling Yu*, Jiahua Shi*, Specific Modification with TPGS and Drug Loading of Cyclodextrin Polyrotaxanes and the Enhanced Antitumor Activity Study in Vitro and in Vivo, ACS Applied Materials & Interfaces, 2019, 11(50), 46427-46436.

 3. Shuling Yu, Qiaoqiao Zhou, Xuliang Zhang, Shuxin Jia, Ying Gan, Yahong Zhang, Jiahua Shi, Jintao Yuan*, Hologram quantitative structure–activity relationship and topomer comparative molecular-field analysis to predict the affinities of azo dyes for cellulose fibers, Dyes and Pigments, 2018, 153, 35–43.

 4. Shuling Yu*, Jintao Yuan, Yi Zhang, Shufang Gao, Ying Gan, Meng Han, Yuewen Chen, Qiaoqiao Zhou, and Jiahua Shi*, Combined HQSAR, topomer CoMFA, homology modeling and docking studies on triazole derivatives as SGLT2 inhibitors, Future Medicinal Chemistry, 2017, 9(9), 847–858.

 5. Jintao Yuan, Shuling Yu*, Shufang Gao, Ying Gan, Yi Zhang, Ting Zhang, Yali Wang, Liu Yang,Jiahua Shi*, Wu Yao**Predicting the biological activities of triazole derivatives as SGLT2 inhibitors using multilayer perceptron neural network, support vector machine, and projection pursuit regression models, Chemometrics and Intelligent Laboratory Systems, 2016, 156, 166–173.

 6. Shuling Yu, Shufang Gao, Ying Gan, Yi Zhang, Xiaojiao Ruan, Yali Wang, Liu Yang, Jiahua Shi*, QSAR models for predicting octanol/water and organic carbon/water partition coefficients of polychlorinated biphenyls. SAR and QSAR in Environmental Research, 2016, 27(4), 249-263.

 7. Shuling Yu*, Jintao Yuan, Jiahua Shi, Xiaojiao Ruan, Yali Wang, Shufang Gao and Yu Du, One-pot synthesis of water-soluble, β-cyclodextrin-based polyrotaxanes in a homogeneous water system and its use in bio-applications. Journal of Materials Chemistry B, 2015, 3, 5277--5283.

 8. Shuling Yu*, Jintao Yuan, Jiahua Shi, Xiaojiao Ruan, Ting Zhang, Yanli Wang, Yu Du, HQSAR and topomer CoMFA for predicting melanocortin-4 receptor binding affinities of trans-4-(4-chlorophenyl) pyrrolidine-3-carboxamides. Chemometrics and Intelligent Laboratory Systems, 2015,146, 34–41.

 9. Shuling Yu*, Xuejie Yuan, Jing Yang, Jintao Yuan, Jiahua Shi, Yali Wang, Yuewen Chen, Shufang Gao, A chemometric-assisted method for the simultaneous determination of malachite green and crystal violet in water based on absorbance–pH data generated by a homemade pH gradient apparatus. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015, 150, 403–408.

 10. Shuling Yu, Yajun Zhang, Xin Wang, Xu Zhen, Zhaoheng Zhang, Wei Wu*, and Xiqun Jiang*, Synthesis of Paclitaxel-Conjugated β-CyclodextrinPolyrotaxane and Its Antitumor Activity,AngewandteChemie International Edition, 2013, 52(28): 7272–7277.

 11. Yuan Cheng, Shuling Yu, Jingjing Wang, Hanqing Qian, Wei Wu, Xiqun Jiang*, In vitro and in vivo Antitumor Activity of Doxorubicin-Loaded Alginic-Acid-Based Nanoparticles,Macromolecular Bioscience, 2012, 12(10), 1326–1335.

 12. Yuan Cheng, Shuling Yu, Xu Zhen, Xin Wang, Wei Wu, Xiqun Jiang*, Alginic Acid Nanoparticles Prepared through Counter-Ion Complexation Method as a Drug Delivery System, ACS Applied Materials & Interfaces, 2012, 4(10), 5325–5332.

 13. Hanqing Qian, Wei Yao, Shuling Yu, Ying Chen, Wei Wu, Xiqun Jiang*, Spontaneous Formation of Giant Polymer Vesicles through a Nucleation and Growth Pathway,Chemistry – An Asian Journal, 2011, 7(8), 1875–1880.

 14. Jingjing Wang, Jialiang Zhang, Shuling Yu, Wei Wu*, Xiqun Jiang*Synthesis and Self-Assembly of a NanoscaledMultiarm Polymer Terminated by β‑Cyclodextrin, ACS Macromolecular Letters, 2013, 2(1), 82–85.

 15. Xiaoqiang Sun*, Shu-Ling Yu, Zheng-Yi Li, Yang Yang,Crystal X-ray diffraction guided NMR analysis of 3,9-diaryl-2,4,8,10-tetraoxaspiro[5.5]undecanes under differently shielding effect of terminal aromatic rings, Journal of Molecular Structure, 2010, 973, 152–156.

 16. 袁金涛,于树玲*,手机成像数字图像法测定血糖,化学教育,20194016),81-83


2、项目

水溶性卟啉封端的β-环糊精聚轮烷的合成及其生物学效应研究(U1404508), 国家自然科学基金项目,2015.01-2017.12,主持

-葡萄糖共转运蛋白2抑制剂虚拟筛选研究(14B350005),河南省教育厅科学技术研究重点项目,2014.01-2015.12,主持

-葡萄糖共转运蛋白-2抑制剂与受体的同源模建、分子对接和构效关系研究(2013YBZR039),河南大学科研基金项目,2014.01-2015.12,主持

水溶性卟啉封端的β-环糊精聚轮烷的合成及其生物学效应研究(yqpy20170071),河南大学优青培育项目,2017.09-2019.08, 主持

特异性环糊精准轮烷修饰的荧光金纳米簇载药材料的制备及其生物学性能研究 (20A430006),河南省教育厅科学技术研究重点项目,2020.01-2021.12,主持

特异性和靶向环糊精准轮烷修饰的金纳米棒药物载体的制备及生物学性能研究(2019002),河南大学医院青年人才科研培育计划项目,2020.01-2021.12,主持

 

 
 

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