汪游清

个人基本信息:汪游清,男,博士,教授

教育经历:2002.09–2007.09 中国科学院大连化学物理研究所,有机化学专业硕博联读,研究生/博士;2008.05 - 2010.04 新加坡国立大学,博士后

工作经历:2007.09 -2008.04 大连联化医药技术有限公司,研发小组长;2010.04至今 河南大学天然药物与免疫工程省重点实验室,历任讲师、副教授、教授

研究方向:1)新型手性催化剂的设计和合成。2)具有潜在生物活性的手性含氮杂环化合物的合成。

学术成就和影响:http://www.researcherid.com/rid/E-9475-2012

1、在河南大学工作期间发表的论文(河南大学单位)

1)Chao-QunZhu,Zhuo-FeiDeng, YahongZhang,You-Qing Wang*, “Synthesis of 4-Substituted 3-(2-Hydroxyphenyl)-quinolines through anUnexpectedIron(III)ChloridePromotedReaction ofCyclicImineDibenzo[b,f][1,4]oxazepines withAlkynes”Org. Chem. Front.,2017,4, 196-203(2).

2)Xiao-Yu Cui, Hui-Xin Duan, Yongna Zhang*,You-Qing Wang*,“Asymmetric Mannich Reaction of Aryl Methyl Ketones with Cyclic Imines Benzo[e][1,2,3]oxathiazine 2,2-Dioxides Catalyzed by Cinchona Alkaloid-based Primary Amines”Chem.Asian J.2016,11, 3118-3125(21).

3)You-Qing Wang*,Zhong-Shu Wei, Chao-Qun Zhu, Yuan-Yuan Ren, Chunrui Wu*“Solvent-controlled andSelectiveSynthesis ofMono- andBis-indolylProducts in BrønstedAcidCatalyzedAza-Friedel-CraftsReactions ofIndoles withCyclicImines”Tetrahedron2016,72, 4643-4654(31).

4)You-Qing Wang*, Yuan-Yuan Ren“Highly Enantioselective Direct Mannich Reaction of Seven-membered CyclicIminesDibenzo[b,f][1,4]oxazepineswithAcetoneviaOrganocatalysis”Chin. J. Catal.2015,36, 93-99(1).

5)Yuan-Yuan Ren,You-Qing Wang*, ShuangLiu“Asymmetric Alkynylation of Seven-Membered Cyclic Imines by Combining Chiral Phosphoric Acids and Ag(I) Catalysts: Synthesis of 11-Substituted-10,11-dihydrodibenzo[b,f][1,4]oxazepine Derivatives”J. Org.Chem.2014,79, 11759-11767(23).

6)You-Qing Wang*,Xiao-Yu Cui, Yuan-Yuan Ren, Yongna Zhang*“Highly Enantioselective and Regioselective Organocatalytic Direct Mannich Reaction of Methyl Alkyl Ketones with Cyclic Imines Benzo[e][1,2,3]oxathiazine 2,2-dioxides”Org. Biomol. Chem.2014,12, 9101-9104(45).

7)Yuan-Yuan Ren,You-Qing Wang*,ShuangLiu,Kun Pan“Organocatalysed Asymmetric Direct Mannich Reaction ofAcetophenone Derivatives and Dibenzo[b,f][1,4]oxazepineswith Azetidine-2-carboxylic Acid”ChemCatChem.2014,6,2985-2992(10).

8)You-Qing Wang*,Yongna Zhang, Kun Pan, Junxiong You,Jin Zhao “Direct Organocatalytic Asymmetric Mannich Addition of 3-Substituted-2H-1,4-Benzoxazines: Access to Tetrasubstituted Carbon Stereocenters”Adv. Synth.Cat.2013,355,3381-3386(17).

9)You-Qing Wang*,Yongna Zhang, Haina Dong, Jie Zhang,Jin Zhao “Phosphane-Catalyzed [3+2] Cycloaddition Reaction of Allenoate and Cyclic Imines: A Simple and Efficient Method for Synthesis of Benzo-Fused Cyclic Sulfamidate Heterocycles”Eur.J. Org. Chem.2013,3764-3770(18).

10)汪游清*,董海娜,张永娜,李杰一锅法从氯磺酰异氰酸酯合成苯并环状亚胺河南大学学报(自然科学版)2013,43, 253 (3).

11)Fangrui Zhong, Xiaoyu Han,Youqing Wang,Yixin Lu* “HighlyEnantioselective [4 + 2]AnnulationsCatalyzed byAminoAcid-basedPhosphines: Synthesis ofFunctionalizedCyclohexenes and 3-Spirocyclohexene-2-oxindoles”Chem. Sci.2012,3, 1231-1234 (4).

12)Xiaoyu Han, Fangrui Zhong,Youqing Wang,Yixin Lu* “Versatile Enantioselective [3+2] Cyclization between Imines and Allenoates Catalyzed by Dipeptide-Based Phosphines”Angew. Chem. Int. Ed.2012,51, 767-770 (3).

13)Xiaoyu Han,Youqing Wang,Fangrui Zhong, Yixin Lu* Enantioselective Morita-Baylis-HillmanReactionPromoted by L-Threonine-derivedPhosphine-thioureaCatalysts.Org. Biomol. Chem.2011,9, 6734-6740 (19).

14)Fangrui Zhong, Xiaoyu Han,Youqing Wang,Yixin Lu* “Highly Enantioselective [3+2] Annulation of Morita–Baylis–Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindoles having Two Contiguous Quaternary Centers”Angew. Chem. Int. Ed.2011,50, 7837-7841(34).

15)Fangrui Zhong,Youqing Wang,Xiaoyu Han, Kuo-Wei Huang*, Yixin Lu* “L-Threonine-Derived Novel Bifunctional Phosphine-Sulfonamide Catalyst-Promoted Enantioselective Aza-Morita-Baylis-Hillman Reaction”Org. Lett.2011,13,1310-1313 (6).

16)Xiaoyu Han,Youqing Wang,Fangrui Zhong, Yixin Lu* “Enantioselective [3 + 2] Cycloaddition of Allenes to Acrylates Catalyzed by Dipeptide-Derived Phosphines: Facile Creation of Functionalized Cyclopentenes Containing Quaternary Stereogenic Centers”J. Am. Chem. Soc.2011,133, 1726-1729 (6).

2、独立工作之前发表的论文

1)Su-Xi Wang,Xiaoyu Han, Fangrui Zhong,Youqing Wang, Yixin Lu* Novel Amino Acid Based Bifunctional Chiral Phosphines.SynLett2011,2766-2778.

2)You-Qing Wang,Chang-Bin Yu, Da-Wei Wang, Yong-Gui Zhou* Enantioselective Synthesis of Cyclic Sulfamidates via Pd-Catalyzed Hydrogenation.Org. Lett.2008,7, 2071-2074.

3)You-Qing Wang,Sheng-Mei Lu, Yong-Gui Zhou* Highly Enantioselective Pd-Catalyzed Asymmetric Hydrogenation of Activated Imines.J. Org. Chem.2007,72,3729-3734.

4)You-Qing Wang,Yong-Gui Zhou* Highly Enantioselective Pd-Catalyzed Asymmetric Hydrogenation of N-Diphenylphosphinyl Ketimines.Synlett.2006,1189-1192.

5)Sheng-Mei Lu,You-Qing Wang,Xiu-Wen Han, Yong-Gui Zhou*Asymmetric Hydrogenation of Quinolines and Isoquinolines Activated by Chloroformates.Angew. Chem. Int. Ed.2006,45, 2260-2263.

6)You-Qing Wang,Sheng-Mei Lu, Yong-Gui Zhou* Palladium-Catalyzed Asymmetric Hydrogenation of Functionalized Ketones.Org. Lett.2005,7, 3235-3238.

7)卢胜梅,汪游清韩秀文,周永贵*均相体系中铱催化2-取代-1,2-二氢喹啉类化合物的脱氢芳构化催化学报2005,26, 287-290.

8)赵玉军,汪游清周永贵*二茂铁衍生的手性硫膦配体在铱催化喹啉不对称氢化中的应用催化学报2005,26, 737-739.

3、项目基金

主持第一

1.国家自然科学基金应急管理项目,21442007,2015年,“亚胺的催化不对称加成合成α位手性氮杂环庚烷”,10万

2.河南大学科研基金优青培育项目,yqpy20140070,2013-2017年,“新型二茂铁骨架的手性双官能亲核膦催化剂的设计合成和在不对称催化中的应用”,25万

3.国家自然科学基金青年基金,21002022,2011-2013年,“新型二茂铁骨架的手性双官能亲核膦催化剂的设计合成和在不对称催化中的应用”,19万

4.教育部第43批留学回国人员科研启动基金,2012年,“新颖的二茂铁骨架双官能亲核膦催化不对称环加成反应的研究”,3万

5.2011年河南省博士后科研基金,2011-2012年,“新型亲核膦催化剂的设计和用于手性药物合成的研究”,5万

6.河南省国际科技合作项目,124300510032,2012-2014年,“富电子二茂铁基叔膦催化联烯的环化反应”

参与

1.河南省教育厅科学技术研究重点项目,14A150029,2014-2015年,“乳液体系中多相催化环状亚胺的不对称Mannich反应研究”,参与第五

2.河南省教育厅科学技术研究重点项目,14A150051,2014-2015年,“新型Indanone催化剂的设计、合成及在不对称Diels-Alder反应中的应用”,参与第三

3.河南省科技厅2011年科技发展计划基础前沿项目,112300410179,2011-2012年,“氨基醇衍生的新型有机分子催化不对称Diels-Alder反应研究”,参与第四

4.国家自然科学基金面上项目,21072044,2011-2013年,“新型手性C2对称双六员环胍催化剂的设计、合成及催化构建单氟代手性化合物反应的研究”,参与第三

5.高等学校博士学科点专项科研基金,2011-2013年,第二,“新型手性C2对称双六员环胍催化剂的设计、合成及催化构建单氟代手性化合物的Mannich反应研究”,参与第二

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