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张亚宏
2017-03-06 18:39   审核人:

女,1982年生,副教授,硕士生导师。2009年毕业于沈阳药科大学生命工程与生物制药学院药理专业,获博士学位,毕业后在河南大学天然药物与免疫工程重点实验室从事药理学方向研究工作,主要从事药物的抗肿瘤机制研究。在国内外发表论文20余篇。

项目:

1.多胺通过调节p-糖蛋白诱导肿瘤细胞多药耐药的机制研究,国家自然科学基金,U1404819

2.蒽醌衍生物抗肝癌作用机制研究,河南省科技厅科技厅基础与前沿技术研究,132300410228

3.靶向性多胺-萘酰亚胺缀合物对肝癌细胞PKC通路的调控,河南省教育厅,2011B310003

4.靶向性多胺-萘酰亚胺缀合物对肝癌细胞PKC信号通路调控的机制研究,博士后基金,20100470995

主要文章:

1.Zhang YH,Wu YL, Cheng Y,Zhao ZK, Tashiro S, Onodera S, andIkejima T*.Fas-mediated autophagy requires JNK activation in HeLa cells,Biochem Biophys Res Commun,377,1205-1210,2008

2.Zhang YH,Wu YL,Wu D, Tashiro S, Onodera S, andIkejima T*. NF-κB facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway,ArchBiochem Biophys,489,25-33,2009

3.Zhang YH,Wu YL,Tashiro S, Onodera S, andIkejima T*. Involvment of PKC signal pathway in oridonin-induced autophagy in HeLa cells: a protective mechanism against apoptosis,Biochem Biophys Res Commun,378,273-278,2009

4.Zhang YH,Wu YL,Tashiro S, Onodera S, andIkejima T*.Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells,Acta Pharmacol Sin,32,1266-1275,2011

5. Wang JH, Luo TW, Li SB,Zhang YH*, Wang CJ, Zhao J*. Synthesis structure-activity relationship and biological activity of acridinederivatives as potent MDR-reversing agents,Curr Med Chem, 20(32), 4070-4079,2013

6.Jianhong Wang, Pengfei Cheng, Tianwei Luo, Zhaoyi Wang,Yahong Zhang* and Jin Zhao*.Synthesis and Preliminary Biological Evaluation of Polyamine-anilineAcridines asP-glycoprotein Inhibitors.Medicinal Chemistry, 10(5), 506-511,2014

7.Jianhong Wang,Huijun Zhao, Zhaoyang Luo, Zhaoyi Wang,Yahong Zhang* and Jin Zhao*.Synthesis and bioloical activity of anthrapyrazoles derivatives as potential antitumor agents.Medicinal Chemistry,10(8), 772-777,2014

8.Yahong Zhang,NanZhang, YankeLi, YanliLu, MingxueLi, and DanyunChen.Synthesis, Crystal Structures, and Cytotoxicity of Thiophene-2-carbaldehyde N(4)-Cyclohexylthiosemicarbazoneand Its Diorganotin(IV) Complex.Synthesis and Reactivity in Inorganic, Metal-Organic,and Nano-Metal Chemistry.45, 191-195,2015

9.张亚宏,甘莹,郭子华,谢松强*.紫草素通过ROS /p38信号通路诱导人宫颈癌HeLa细胞凋亡,中国药理学通报,27(6), 864-867,2011

10.张亚宏,郭敬功,郭子华,谢松强*.白藜芦醇通过激活p38-p53通路诱导人乳腺癌MCF-7细胞凋亡,药学学报, 46(11),1332-1337,2011

11.张亚宏,甘莹,齐建国,王建红*.米托蒽醌通过活性氧诱导大鼠肝癌RH35细胞凋亡的研究,中国畜牧兽医,43(12),3245-3250,2016

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