程建军
校聘副教授，硕士生导师
邮箱：chengjj@henu.edu.cn
个人简介
博士，河南大学校聘副教授，硕士生导师，天然药物创新与转化重点实验室研究生党支部书记，石家华教授团队成员。2022年博士毕业于哈尔滨工业大学，主要从事天然产物自组装小分子载药体系在抗微生物/抗肿瘤方面的基础研究。目前主持河南省级科技研发计划联合基金、科技攻关等项目，并参与国家自然科学基金面上项目。以第一作者/第一通讯在Acta Pharmaceutica Sinica B, Small, ACS Applied Materials &Interfaces等国际期刊上发表学术论文14篇，授权中国发明专利4项。
教育经历
2017-09 至 2021-12 哈尔滨工业大学，化学工程与技术，博士
2014-09 至 2017-07 哈尔滨师范大学，有机化学，硕士（推免）
2010-09 至 2014-07 哈尔滨师范大学，制药工程，学士
科研与学术工作经历
2024-03 至 今, 河南大学, 河南省天然药物创新与转化重点实验室, 讲师
2022-02 至 2024-03, 河南大学, 河南省天然药物与免疫工程重点实验室, 讲师
研究方向
天然产物自组装小分子载药体系抗微生物/抗肿瘤研究
主持科研项目
1. 河南省级科技研发计划联合基金，2022.09-2024.09，20 万，主持，在研。
2. 河南省重点研发与推广专项（科技攻关），2023.01-2024.12，0 万，主持，在研。
代表性研究论文
1) Zhou C.L., Zhao, S., Zhang, Y. B., Cheng, J.J.,* Shi, J.H.,* Du G. H *, Mesoporous polydopamine targeting CDK4/6 inhibitor toward brilliant synergistic immunotherapy of breast cancer. Small, 2024, 202310565 (SCI, Top, IF:13.3)
2) Cheng, J.J., Zhao, H.T., Li, B., Zhang, H., Shi, J.H., Yang, X*, et al., Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy. Acta. Pharm. Sin. B. 2023, 13，879-896 (SCI, Top, IF:14.9)
3) Cheng, J.J., Li, X.Y., Wang, S., Han, Y., Zhao, H.T., and Yang, X*. Carrier-free triterpene prodrugs with glutathione response and biosafety for synergistically enhanced photochemotherapy. ACS Appl. Mater. Interfaces. 2021, 13, 245-256. (SCI, Top, IF:10.38)
4) Cheng, J.J., Wang, S., Zhao, H.T., Liu, Y., and Yang, X*. Exploring self-assembly mechanism and effective synergistic antitumor chemophototherapy of biodegradable and glutathione responsive ursolic acid prodrug mediated photosensitive nanodrug. Biomater. Sci., 2021, 9, 3762-3775. (SCI, IF:6.843)
5) Cheng, J.J., Fu, S.Y., Qin, Z., Han, Y., and Yang, X*. Self-assembled natural small molecule diterpene acids with favorable anticancer activity and biosafety for synergistically enhanced antitumor chemotherapy. J. Mater. Chem. B, 2021, 9, 2674-2687. (SCI, Top, IF:6.331)
6) 程建军,杨鑫*.三萜天然小分子自组装机制及其协同抗癌应用研究.药学学报, 2021, 56, 2102-2111.
7) Cheng, J.J., Zhao, H.T., Wang, J.C., Han, Y., and Yang, X*. Bioactive natural small molecule-tuned coassembly of photosensitive drugs for highly efficient synergistic and enhanced type i photochemotherapy. ACS Appl. Mater. Interfaces. 2020, 12, 43488-43500. (SCI, Top, IF:10.38)
8) Cheng, J.J., Zhao, H.T., Yao, L., Li, Y., * Qi, B.K., Wang, J., and Yang, X*. Simple and multifunctional natural self-assembled sterols with anticancer activity-mediated supramolecular photosensitizers for enhanced antitumor photodynamic therapy. ACS Appl. Mater. Interfaces. 2019, 11, 29498-29511. (SCI, Top, IF:10.38)
9) Cheng, J.J., Li W.T., Tan, G.H., Wang, Z.Q., Li, S.Y., Jin, Y.X. *, Synthesis and in vitro photodynamic therapy of chlorin derivative 131-ortho-trifluoromethyl-phenylhydrazone modified pyropheophorbide-a. Biomed. Pharmacother. 2017, 87, 263–273. (SCI, IF:7.5)
10) Zhang, H.Y#., Cheng, J.J#., Li W.T., Tan, G.H., Wang, Z.Q., Jin, Y.X*. Facile synthesis of a highly water-soluble graphene conjugated chlorophyll-a photosensitizer composite for improved photodynamic therapy in vitro. New. J. Chem., 2017, 41, 10069-10082. (SCI, IF:3.591)
11) Cheng, J.J., Tan, G.H., Li W.T., Zhang, H.Y., Wu, X.D., Wang, Z.Q., Jin, Y.X*. Facile synthesis of chitosan assisted multifunctional magnetic Fe3O4@SiO2@CS@pyropheophorbide-a fluorescent nanoparticles for photodynamic therapy. New. J. Chem., 2016, 40, 8522-8534. (SCI, IF:3.591)
12) Cheng, J.J., Tan, G.H., Li W.T., Li, J.H., Wang, Z.Q., Jin, Y.X*. Preparation, characterization and in vitro photodynamic therapy of a pyropheophorbide-a-conjugated Fe3O4 multifunctional magnetofluorescence photosensitizer. RSC Adv. 2016, 6, 37610-37620. (SCI, IF:3.361)
13) Li W.T#., Tan, G.H#., Cheng, J.J#., Wang, Z.Q., Jin, Y.X*. A novel photosensitizer 31,131-phenylhydrazine -Mppa (BPHM) and its in vitro photodynamic therapy against HeLa cells. Molecules 2016, 21, 558. (SCI, IF:4.6)
授权专利
1. 一种活性天然超分子光敏剂的制备方法及其应用，授权号：ZL 2019103007950
2. 一种活性天然小分子介导的共组装光敏药物的制备方法及应用，授权号：ZL 2020104143052
3. 一种萜类小分子组装的氧化还原响应光敏药物的制备方法，授权号：ZL 2020104968229
4. 一种壳寡糖修饰的白桦脂酸药物运输体系的制备方法及其应用，授权号：ZL 2020105690719
欢迎具有有机合成、天然药物化学、生物医学工程等专业背景的优秀学生加盟我们温馨、科研氛围浓郁的大家庭（或联系石家华教授：sjiahua@henu.edu.cn），携手并进。
