张亚宏
副教授，硕士生导师
邮箱：zhangyahong@vip.henu.edu.cn
个人简介
副教授。主持完成国家项目1项，省科技厅项目2项，省教育厅项目2项，博士后基金1项。在国内外重要学术期刊发表论文40余篇。指导毕业10余名硕士研究生。
教育经历
2004-07 至 2009-06, 沈阳药科大学, 药理学, 博士
2000-07 至 2004-06, 沈阳药科大学, 药学, 学士
博士后工作经历
2010-01 至 2014-12, 河南大学
科研与学术工作经历
2024-03 至 今, 河南大学, 河南省天然药物创新与转化重点实验室, 副教授
2012-05 至 2024-03, 河南大学, 河南省天然药物与免疫工程重点实验室, 副教授
2009-07 至 2012-04, 河南大学, 河南省天然药物与免疫工程重点实验室, 讲师
研究方向
药理学
主要从事药物的抗肿瘤机制研究；肿瘤多药耐药的发生机制研究以及药物抗肿瘤多药耐药的机制研究。
主持科研项目
1. 河南省科技厅，BP1 在非小细胞肺癌顺铂耐药中的作用及机制研究，项目号：242102310311，2024.01-2025.12，主持，在研。
2. 河南省教育厅，基于微管靶点的四氢喹喔啉类化合物A3抗肿瘤多药耐药作用及其机制研究，项目号：20A310003，3万，2020.01-2021.12，主持，结项。
3. 国家自然科学基金，多胺通过调节p-糖蛋白诱导肿瘤细胞多药耐药的机制研究，项目号：U1404819，30万，2015.01-2017.12，主持，结项。
4. 河南省科技厅，蒽醌衍生物抗肝癌作用机制研究，项目号：132300410228，2013.01-2015.12，主持，结项。
5. 河南省教育厅，靶向性多胺-萘酰亚胺缀合物对肝癌细胞PKC通路的调控，项目号：2011B310003，2011.01-2013.12，主持，结项。
6. 博士后基金，靶向性多胺－萘酰亚胺缀合物对肝癌细胞信号PKC通路调控的机制研究，项目号：20100470995，3万，2010.01-2013.12，主持，结项。
代表性研究论文
1. Liang Tingting; Dong Haiyang; Wang Zhuangzhuang; Lu Lu; Song Xueting; Qi Jianguo; Zhang Yahong*; Wang Jianhong*; Du Guanhua*. Discovery of novel urea derivatives as ferroptosis and autophagy inducer for human colon cancer treatment. European Journal of Medicinal Chemistry, 2024, 268:116277.
2. Liang Tingting; Zhou Xiaomin; Lu Lu; Dong Haiyang; Zhang Yanan; Xu Yungen; Qi Jianguo; Zhang Yahong*; Wang Jianhong*. Structure-activity relationships and antiproliferative effects of 1,2,3,4-4H-quinoxaline derivatives as tubulin polymerization inhibitors, Bioorganic Chemistry, 2021, 110: 104793.
3. Xing Cuili; Fang Yan; Jiang Lei; Zhang Yahong*; Li Mingxue*. Diorganotin(IV) complexes derived from N-terminal methylation of Triapine: synthesis, characterization and antibacterial activity evaluation, Journal of Organometallic Chemistry, 2020, 911: 12115.
4. Qi Jianguo; Huang Jing; Zhou Xiaomin; Luo Wen; Xie Jiaxin; Niu Linqiang; Yan Zhijie; Lu Yang; Men Yuhui; Chen Yanan; Zhang Yahong*; Wang Jianhong*. Synthesis and biological evaluation of quinoxaline derivatives as tubulin polymerization inhibitors that elevate intracellular ROS and triggers apoptosis via mitochondrial pathway, Chemical Biology & Drug Design, 2019, 93(4): 617-627.
5. Qi Jianguo; Dong Haiyang; Huang Jing; Zhang Shufeng; Niu Linqiang; Zhang Yahong*; Wang Jianhong*. Synthesis and biological evaluation of N-substituted 3-oxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid derivatives as tubulin polymerization inhibitors, European Journal of Medicinal Chemistry, 2018, 143: 8-20.
6. Fang Yan, Wang Yuting, Zhao Meng, Lu Yanli, Li Mingxue*, Zhang Yahong*. Bismuth(III) and diorganotin(IV) complexes of bis(2-acetylpyridine) thiocarbonohydrazone: synthesis, characterization, and apoptosis mechanism of action in vitro. Polyhedron, 2018, 155, 254-260.
7. Wu Yuanyuan; Wang Yuting; Wang Yingying; Li Mingxue*; Lu Yanli; Zhang Yahong*. Dimethyltin(IV) and palladium(II) complexes derived from 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone: Synthesis, crystal structures and biological evaluation, Inorganic Chemistry Communications, 2017, 78: 65-69.
8. Zhang Yahong, Zhang Nan, Li Yanke, Lu Yanli, Li Mingxue*, and Danyun Chen. Synthesis, crystal structures, and cytotoxicity of thiophene-2-carbaldehyde N(4)- cyclohexylthiosemicarbazone and its diorganotin(IV) complex. Synthesis and Reactivity in In organic, Metal-Organic, and Nano-Metal Chemistry, 2015, 45:191-195.
7. Wang Jianhong, Cheng Pengfei, Luo Tianwei, Wang Zhaoyi, Zhang Yahong*, Zhao Jin *. Synthesis and preliminary biological evaluation of polyamine-aniline acridines as p-glycoprotein inhibitors. Medicinal Chemistry, 2014, 10(5): 506-511.
8. Wang Jianhong, Luo Tianwei, Li Shaobin, Zhang Yahong*, Wang Chaojie, Zhao Jin*. Synthesis, structure-activity relationship and biological activity of acridine derivatives as potent MDR-reversing agents. Current Medicinal Chemistry, 2013, 20, 4070-4079.
