石家华
教授，硕/博士生导师
邮箱：sjiahua@henu.edu.cn
个人简介
河南省三级教授，河南省高层次人才，河南省学术技术带头人，河南省教育厅学术技术带头人，河南省化学会常务理事，河南省天然药物创新与转化重点实验室常务副主任，抗病毒性传染病创新药物全国重点实验室（河南大学）副主任。主持完成国家项目1项，省科技厅项目2项，省教育厅项目1项。在ACS Applied Materials & Interfaces, International Journal of Pharmaceutics, Journal of Materials Chemistry B, Journal of Nanobiotechnology等国内外重要学术期刊发表SCI收录论文50余篇，授权发明专利3件。
教育经历
2002-09 至 2005-07, 中国科学院化学研究所, 物理化学，博士
1999-09 至 2002-07, 河南大学, 高分子化学和物理，硕士
1991-09 至 1995-07, 河南大学, 化学，学士
博士后工作经历
2006-02 至 2009-01, 新加坡国立大学
科研与学术工作经历
2010-10 至 今, 河南大学, 河南省天然药物创新与转化重点实验室, 教授
2009-02 至 2010-09, 河南大学, 河南省天然药物与免疫工程重点实验室, 副教授
2005-11 至 2009-01, 河南大学, 化学化工学院, 副教授
2000-11 至 2005-10, 河南大学, 化学化工学院, 讲师
讲授课程
承担《材料分析测试技术》等本、硕课程。
研究方向
主要从事抗菌抗病毒抗肿瘤生物医学材料研究。
主持科研项目
1. 国家自然科学基金，题目：碳纳米管/聚苯胺/金纳米复合体系的构建及电输运性能研究，项目号：21073054，34万，2011.01-203.12，主持，结项。
2. 河南省科技厅，碳纳米管/量子点复合材料靶向标记识别肿瘤细胞研究，项目号：102300410180，0万，2010.02-203.12，主持，结项。
3. 河南省科技厅，强粘附性抗菌水凝胶的制备研究，项目号：192102210021，10万，2019.01-2022.10，主持，结项。
4. 河南省教育厅重点科研项目，聚甲醛/功能化碳纳米管复合材料的结晶性和相容性的研究，项目号：14A430013，2万，2014.01-2015.12，主持，结项。
5. 横向开发课题，题目：负载型压电催化抗微生物材料的开发及其微孔净水膜应用，100万，2023.10-2026.10，主持，在研。
代表性研究论文
1. Junqing Zhang, Shuang Zhao, Shen Zhang, Hao Zhu, Yaoxin Zhang, Linpei Li, Chaoqun Liu* and Jiahua Shi*, A nanozyme-reinforced injectable photodynamic hydrogel for combating biofilm infection, J. Mater. Chem. B, 2023, 11, 10108-10120.
2. Hao Zhu, Xuedan Cheng, Junqing Zhang, Qiang Wu, Chaoqun Liu* and Jiahua Shi*, Constructing a self-healing injectable SABA/Borax/PDA@AgNPs hydrogel for synergistic low-temperature photothermal antibacterial therapy, J. Mater. Chem. B, 2023, 11, 618-630.
3. Peng Hu, Shuang Zhao*, Jiahua Shi*, Fan Li, Shaochen Wang, Ying Gan, Lei Liu, and Shuling Yu, Precisely NIR-II-activated and pH-responsive cascade catalytic nanoreactor for controlled drug release and self-enhanced synergetic therapy, Nanoscale, 2022, 14, 12219.
4. Ying Gan, Chen Lin, Hao Zhu, Xuedan Cheng, Chaoqun Liu* and Jiahua Shi*, An injectable self-healing CS/PDA–AgNPs hybrid hydrogel for mild and highly-efficient photothermal sterilization, New J. Chem., 2022, 46, 8043–8052.
5. Shaochen Wang, Qiaoqiao Zhou, Shuling Yu*, Shuang Zhao, Jiahua Shi* and Jintao Yuan*, Rod-like hybrid nanomaterial with tumor targeting and pH-responsive for cancer chemo/photothermal synergistic therapy, Journal of Nanobiotechnology, 2022, 20, 332.
6. Shanshan Li, Kunpeng Lin, Peng Hu, Shaochen Wang, Shuang Zhao*, Ying Gan, Lei Liu, Shuling Yu, Jiahua Shi*, A multifunctional nanoamplifier with self-enhanced acidity and hypoxia relief for combined photothermal/photodynamic/starvation therapy, International Journal of Pharmaceutics, 2022, 611, 121307.
7. Shuxin Jia, Shaochen Wang, Shanshan Li, Peng Hu, Shuling Yu*, Jiahua Shi*, Jintao Yuan*, Specific modification and self-transport of porphyrins and their multi-mechanism cooperative antitumor studies dagger, Journal of Materials Chemistry B, 2021, 9(4), 3180-3191.
8. Qiaoqiao Zhou, Shaochen Wang, Peng Hu, Shuling Yu*, Jiahua Shi* and Jintao Yuan*, Targeted and Specific Modification with 4-Carboxybenzeneboronic Acid and TPGS of Fluorescent Gold Nanoparticles and the Enhanced Antitumor Activity Research, Particle & Particle Systems Characteriztion, 2021, 38(4), 2000333.
9. Kunpeng Lin, Ying Gan, Peide Zhu, Shanshan Li, Chen Lin, Shuling Yu, Shuang Zhao, Jiahua Shi* , Runming Li*, Jinfang Yuan, Hollow mesoporous polydopamine nanospheres: synthesis, biocompatibility and drug delivery, Nanotechnology, 2021, 32 (28), 285602.
10. Shanshan Li, Ying Gan, Chen Lin, Kunpeng Lin, Peng Hu, Lei Liu, Shuling Yu, Shuang Zhao*, Jiahua Shi*, NIR-/pH-Responsive Nanocarriers Based on Mesoporous Hollow Polydopamine for Codelivery of Hydrophilic/Hydrophobic Drugs and Photothermal Synergetic Therapy, ACS Applied Bio Materials, 2021, 4(2), 1605-1615.
11. Lei Liu, Shuaichao Wang, Peilan Qi, Shiyong Song*, Yanwei Yang, Jiahua Shi*, Guang Han*, Dopamine-modified poly(ε-caprolactone) micelles for pH controlled delivery of bortezomib, International Journal of Pharmaceutics, 2020, 590, 119885.
12. Yi Zhang, Shuxin Jia, Jintao Yuan, Peide Zhu, Ying Gan, Guangfang Fan, Shuling Yu,* Jiahua Shi*, Porphyrin-terminated nanoscale fluorescent polyrotaxane as a biodegradable drug carrier for anticancer research, Nanotechnology, 2020, 31 (25), 255101.
13. Peide Zhu, Ying Gan, Kunpeng Lin, Chen Lin, Shanshan Li, Shuling Yu, Jiahua Shi*, Dual-Response Detection of Oxidized Glutathione, Ascorbic Acid, and Cell Imaging Based on pH/Redox Dual-Sensitive Fluorescent Carbon Dots, ACS Omega, 2020, 5(9), 4482-4489.
14. Yi Zhang, Qiaoqiao Zhou, Shuxin Jia, Kunpeng Lin, Guangfang Fan, Jintao Yuan, Shuling Yu,* Jiahua Shi*, Specific Modification with TPGS and Drug Loading of Cyclodextrin Polyrotaxanes and the Enhanced Antitumor Activity Study in Vitro and in Vivo, ACS Appl. Mater. Interfaces, 2019, 11(50), 46427−46436.
15. Yao Xiong, Tian Hou, Lei Liu, Wanjia Peng, Chunyun Wang, Yan Lu, Shuaichao Wang, Jiahua Shi*, Shiyong Song*, Solanesol derived therapeutic carriers for anticancer drug delivery, International Journal of Pharmaceutics, 2019, 572, 118823.
16. Shuling Yu*, Jintao Yuan, Yi Zhang, Shufang Gao, Ying Gan, Meng Han, Yuewen Chen, Qiaoqiao Zhou, Jiahua Shi*, Combined HQSAR, topomer CoMFA, homology modeling and docking studies on triazole derivatives as SGLT2 inhibitors, Future Medicinal Chemistry, 2017, 9(9): 847-858.
17. Runming Li，Zhiyuan Li，Qiang Wu，Dongfeng Li，Jiahua Shi*，Yuewen Chen，Shuling Yu，Tao Ding，Congzhen Qiao，One-step synthesis of monodisperse AuNPs@PANI composite nanospheres as recyclable catalysts for 4-nitrophenol reduction，Journal of Nanoparticle Research，2016 18：142.
18. Yongwei Huang*, Weiguang Zhang, Junchao Wang, Lina Fu, Jiahua Shi*, Electron-withdrawing groups induced remarkable changes in sensory property based on single micro/nanostructure of perylenediimide derivatives. Materials Chemistry and Physics, 2015, 151, 93-98.
19. Xianhe Huang, Mengmeng Zhang, Xinwei Dou, Xuan Lu, Yujun Qin*, Pu Zhang, Jiahua Shi*, Zhixin Guo, Strengthened graphene oxide/diazoresin multilayer composites from layer-by-layer assembly and cross-linking. Chinese Chemical Letters, 2015, 26, 1155-1157.
20. Quanhui Guo, Shuangshuang Zou, Juan Li, Dongfeng Li, Hexian Jiao, Jiahua Shi*, Facile synthesis of morphology- and size-controllable polythiophene/gold composites in aqueous medium. Journal of Nanoparticle Research 2014, 16, 2702.
21. Yuchao Ma, Mengmeng Xue, Jiahua Shi*, Yiwei Tan*. Large-scale, solution-phase growth of semiconductor nanocrystals into ultralong one dimensional arrays and electrical properties. Nanoscale 2014, 6, 6828-6836.
22. Qiang Wu*, Qiaofang Qi, Chao Zhao, Chaoqun Liu, Luna Fan, Wenzong Zhang, Jiahua Shi* and Dongjie Guo, A hybrid proteolytic and antibacterial bifunctional film based on amphiphilic carbonaceous conjugates of trypsin and vancomycin, Journal of Materials Chemistry B, 2014, 2, 1681-1688.
23. Yongwei Huang, Junchao Wang, Lina Fu, Wenfeng Kuang, Jiahua Shi*. Effect of Core-substituted Groups on Sensing Properties Based on Single Micro/nanorod of Perylenediimide Derivatives. Sensors and Actuators B: Chemical 2013, 188, 411-416.
24. Jiahua Shi*, Qiang Wu, Runming Li, Yinxu Zhu, Yujun Qin, Congzhen Qiao. pH-Controlled Morphology Transition of Polyaniline from Nanofibers to Nanosphere, Nanotechnology, 2013, 24(17), 175602.
25. Qiang Wu, Chaoqun Liu, Luna Fan, Jiahua Shi*, Huanxia Jia, Qiaofang Qi, Zhiqiang Liu. Heparinized hierarchically hollow hydroxyapatite microspheres as bone substitute: Fabrication and controlled delivery of growth factors, RSC Advances 2013, 3, 7486-7494.
26. Qiang Wu, Chaoqun Liu, Luna Fan, Jiahua Shi*, Zhiqiang Liu, Ruifang Li, Liwei Sun. Heparinized magnetic mesoporous silica nanoparticles as multifunctional growth factor delivery carriers, Nanotechnology, 2012, 23 (48), 485703.
27. Jia-Hua Shi, Bing-Xing Yang, Suat Hong Goh. Covalent functionalization of multiwalled carbon nanotubes with poly(styrene-co-acrylonitrile) by reactive melt blending, European Polymer Journal, 2009, 45 1002-1008.
28. Jia-Hua Shi, Bing-Xing Yang, K. P. Pramoda, Suat Hong Goh. Enhancement of the Mechanical Performance of Poly(vinyl chloride) Using Poly(n-butyl methacrylate)-grafted Multiwalled Carbon Nanotubes, Nanotechnology, 2007, 18, 375704.
29. Jiahua Shi, Zhiyong Chen, Yujun Qin, Zhi-Xin Guo. Multiwalled Carbon Nanotube Microspheres from Layer-by-Layer Assembly and Calcination, J. Phys. Chem. C, 2008, 112, 11617-11622.
30. Jiahua Shi, Yujun Qin, Zhi-Xin Guo, Daoben Zhu. Covalently attached multilayer Self-Assemblies of Single-Walled Carbon Nanotubols and Diazoresins, Nanotechnology, 2007, 18, 365704.
31. Jiahua Shi, Zhi-Xin Guo, Bohan Zhan, Yongfang Li, Daoben Zhu. Actuators Based on PVA/MWNT Hydrogels, J. Phys. Chem. B, 2005, 109, 14789-14791.
32. Jiahua Shi, Yujun Qin, Wei Wu, Xianglong Li, Zhi-Xin Guo, Daoben Zhu. In situ Synthesis of CdS Nanoparticles on Multi-walled Carbon Nanotubes, Carbon, 2004, 42, 465-468.
33. Jiahua Shi, Xun Sun, Chunhe Yang, Qingyu Gao, Yongfang Li. Electrochemical Synthesis of Polythiophene in an Ionic Liquid, Chinese Chemical Letters, 2002, 13, 306-307.
授权专利
1. 一种石墨烯改性聚甲醛复合材料的制备方法，授权号：ZL 201410137947.7
2. 一种棒状杂化纳米材料、含其的药物及其制备方法，授权号：ZL 202010144910.1
3. 特异性卟啉自运输纳米载体材料及其制备方法，授权号：ZL 202011109685.5
参编专著、教材
1.十五国家重点图书《功能材料化学进展》第五章《碳纳米管的化学修饰》，化学工业出版社，2005.08
获得奖励及荣誉
1. 2009年河南省高校青年骨干教师
2. 2010年河南省教育厅学术技术带头人
3. 2011年河南省学术技术带头人
4. 2020年河南省高层次（C类）人才
