石家华
教授，硕/博士生导师
邮箱：sjiahua@henu.edu.cn
个人简介
河南省三级教授。河南省高层次人才，河南省学术技术带头人，河南省教育厅学术技术带头人，河南化学会常务理事，河南省天然药物创新与转化重点实验室常务副主任，抗病毒性传染病创新药物全国重点实验室（河南大学）副主任。主持完成国家项目1项，省科技厅项目2项，省教育厅项目1项。在ACS Applied Materials & Interfaces, International Journal of Pharmaceutics, Journal of Materials Chemistry B, Journal of Nanobiotechnology等国内外重要学术期刊发表SCI收录论文50余篇，授权发明专利3件。
教育经历
2002-09 至 2005-07, 中国科学院化学研究所, 物理化学，博士
2019-09 至 2002-07, 河南大学, 高分子化学和物理，硕士
1991-09 至 1995-07, 河南大学, 化学，学士
博士后工作经历
2006-02 至 2009-01, 新加坡国立大学
科研与学术工作经历
2010-10 至 今, 河南大学, 河南省天然药物创新与转化重点实验室, 教授
2009-02 至 2010-09, 河南大学, 河南省天然药物与免疫工程重点实验室, 副教授
2005-11 至 2009-01, 河南大学, 化学化工学院, 副教授
2000-11 至 2005-10, 河南大学, 化学化工学院, 讲师
讲授课程
承担《材料分析测试技术》等本、硕课程。
研究方向
主要从事抗菌抗病毒抗肿瘤生物医学材料研究。
主持科研项目
1. 国家自然科学基金，题目：碳纳米管/聚苯胺/金纳米复合体系的构建及电输运性能研究，项目号：21073054，34万，2011.01-203.12，主持，结项。
2. 河南省科技厅，碳纳米管/量子点复合材料靶向标记识别肿瘤细胞研究，项目号：102300410180，0万，2010.02-203.12，主持，结项。
3. 河南省科技厅，强粘附性抗菌水凝胶的制备研究，项目号：192102210021，10万，2019.01-2022.10，主持，结项。
4. 河南省教育厅重点科研项目，聚甲醛/功能化碳纳米管复合材料的结晶性和相容性的研究，项目号：14A430013，2万，2014.01-2015.12，主持，结项。
5. 横向开发课题，题目：负载型压电催化抗微生物材料的开发及其微孔净水膜应用，100万，2023.10-2026.10，主持，在研。
代表性研究论文
1. Junqing Zhang, Shuang Zhao, Shen Zhang, Hao Zhu, Yaoxin Zhang, Linpei Li, Chaoqun Liu* and Jiahua Shi*, A nanozyme-reinforced injectable photodynamic hydrogel for combating biofilm infection, J. Mater. Chem. B, 2023, 11, 10108-10120.
2. Hao Zhu, Xuedan Cheng, Junqing Zhang, Qiang Wu, Chaoqun Liu* and Jiahua Shi*, Constructing a self-healing injectable SABA/Borax/PDA@AgNPs hydrogel for synergistic low-temperature photothermal antibacterial therapy, J. Mater. Chem. B, 2023, 11, 618-630.
3. Peng Hu, Shuang Zhao*, Jiahua Shi*, Fan Li, Shaochen Wang, Ying Gan, Lei Liu, and Shuling Yu, Precisely NIR-II-activated and pH-responsive cascade catalytic nanoreactor for controlled drug release and self-enhanced synergetic therapy, Nanoscale, 2022, 14, 12219.
4. Ying Gan, Chen Lin, Hao Zhu, Xuedan Cheng, Chaoqun Liu* and Jiahua Shi*, An injectable self-healing CS/PDA–AgNPs hybrid hydrogel for mild and highly-efficient photothermal sterilization, New J. Chem., 2022, 46, 8043–8052.
5. Shaochen Wang, Qiaoqiao Zhou, Shuling Yu*, Shuang Zhao, Jiahua Shi* and Jintao Yuan*, Rod-like hybrid nanomaterial with tumor targeting and pH-responsive for cancer chemo/photothermal synergistic therapy, Journal of Nanobiotechnology, 2022, 20, 332.
6. Jinghua Li*, Jianbo Zhang, Xibin Jiao, Jiahua Shi*, Jiangxue Ye, Ken Song, Jianfeng Bao, Guangda Li, Kun Lei*, NIR-driven PtCu-alloy nanocages via photothermal enhanced fenton catalytic degradation of pollutant dyes under neutral pH, Journal of Alloys and Compounds，2022, 895, 162624.
7. Shanshan Li, Kunpeng Lin, Peng Hu, Shaochen Wang, Shuang Zhao*, Ying Gan, Lei Liu, Shuling Yu, Jiahua Shi*, A multifunctional nanoamplifier with self-enhanced acidity and hypoxia relief for combined photothermal/photodynamic/starvation therapy, International Journal of Pharmaceutics, 2022, 611, 121307.
8. Shuxin Jia, Shaochen Wang, Shanshan Li, Peng Hu, Shuling Yu*, Jiahua Shi*, Jintao Yuan*, Specific modification and self-transport of porphyrins and their multi-mechanism cooperative antitumor studies dagger, Journal of Materials Chemistry B, 2021, 9(4), 3180-3191.
9. Qiaoqiao Zhou, Shaochen Wang, Peng Hu, Shuling Yu*, Jiahua Shi* and Jintao Yuan*, Targeted and Specific Modification with 4-Carboxybenzeneboronic Acid and TPGS of Fluorescent Gold Nanoparticles and the Enhanced Antitumor Activity Research, Particle & Particle Systems Characteriztion, 2021, 38(4), 2000333.
10. Kunpeng Lin, Ying Gan, Peide Zhu, Shanshan Li, Chen Lin, Shuling Yu, Shuang Zhao, Jiahua Shi* , Runming Li*, Jinfang Yuan, Hollow mesoporous polydopamine nanospheres: synthesis, biocompatibility and drug delivery, Nanotechnology, 2021, 32 (28), 285602.
11. Shanshan Li, Ying Gan, Chen Lin, Kunpeng Lin, Peng Hu, Lei Liu, Shuling Yu, Shuang Zhao*, Jiahua Shi*, NIR-/pH-Responsive Nanocarriers Based on Mesoporous Hollow Polydopamine for Codelivery of Hydrophilic/Hydrophobic Drugs and Photothermal Synergetic Therapy, ACS Applied Bio Materials, 2021, 4(2), 1605-1615.
12. Lei Liu, Shuaichao Wang, Peilan Qi, Shiyong Song*, Yanwei Yang, Jiahua Shi*, Guang Han*, Dopamine-modified poly(ε-caprolactone) micelles for pH controlled delivery of bortezomib, International Journal of Pharmaceutics, 2020, 590, 119885.
13. Yi Zhang, Shuxin Jia, Jintao Yuan, Peide Zhu, Ying Gan, Guangfang Fan, Shuling Yu,* Jiahua Shi*, Porphyrin-terminated nanoscale fluorescent polyrotaxane as a biodegradable drug carrier for anticancer research, Nanotechnology, 2020, 31 (25), 255101.
14. Peide Zhu, Ying Gan, Kunpeng Lin, Chen Lin, Shanshan Li, Shuling Yu, Jiahua Shi*, Dual-Response Detection of Oxidized Glutathione, Ascorbic Acid, and Cell Imaging Based on pH/Redox Dual-Sensitive Fluorescent Carbon Dots, ACS Omega, 2020, 5(9), 4482-4489.
15. Yi Zhang, Qiaoqiao Zhou, Shuxin Jia, Kunpeng Lin, Guangfang Fan, Jintao Yuan, Shuling Yu,* Jiahua Shi*, Specific Modification with TPGS and Drug Loading of Cyclodextrin Polyrotaxanes and the Enhanced Antitumor Activity Study in Vitro and in Vivo, ACS Appl. Mater. Interfaces, 2019, 11(50), 46427−46436.
16. Yao Xiong, Tian Hou, Lei Liu, Wanjia Peng, Chunyun Wang, Yan Lu, Shuaichao Wang, Jiahua Shi*, Shiyong Song*, Solanesol derived therapeutic carriers for anticancer drug delivery, International Journal of Pharmaceutics, 2019, 572, 118823.
17. Shuling Yu*, Jintao Yuan, Yi Zhang, Shufang Gao, Ying Gan, Meng Han, Yuewen Chen, Qiaoqiao Zhou, Jiahua Shi*, Combined HQSAR, topomer CoMFA, homology modeling and docking studies on triazole derivatives as SGLT2 inhibitors, Future Medicinal Chemistry, 2017, 9(9): 847-858.
18. Runming Li，Zhiyuan Li，Qiang Wu，Dongfeng Li，Jiahua Shi*，Yuewen Chen，Shuling Yu，Tao Ding，Congzhen Qiao，One-step synthesis of monodisperse AuNPs@PANI composite nanospheres as recyclable catalysts for 4-nitrophenol reduction，Journal of Nanoparticle Research，2016 18：142.
19. Yongwei Huang*, Weiguang Zhang, Junchao Wang, Lina Fu, Jiahua Shi*, Electron-withdrawing groups induced remarkable changes in sensory property based on single micro/nanostructure of perylenediimide derivatives. Materials Chemistry and Physics, 2015, 151, 93-98.
20. Xianhe Huang, Mengmeng Zhang, Xinwei Dou, Xuan Lu, Yujun Qin*, Pu Zhang, Jiahua Shi*, Zhixin Guo, Strengthened graphene oxide/diazoresin multilayer composites from layer-by-layer assembly and cross-linking. Chinese Chemical Letters, 2015, 26, 1155-1157.
21. Quanhui Guo, Shuangshuang Zou, Juan Li, Dongfeng Li, Hexian Jiao, Jiahua Shi*, Facile synthesis of morphology- and size-controllable polythiophene/gold composites in aqueous medium. Journal of Nanoparticle Research 2014, 16, 2702.
22. Yuchao Ma, Mengmeng Xue, Jiahua Shi*, Yiwei Tan*. Large-scale, solution-phase growth of semiconductor nanocrystals into ultralong one dimensional arrays and electrical properties. Nanoscale 2014, 6, 6828-6836.
23. Qiang Wu*, Qiaofang Qi, Chao Zhao, Chaoqun Liu, Luna Fan, Wenzong Zhang, Jiahua Shi* and Dongjie Guo, A hybrid proteolytic and antibacterial bifunctional film based on amphiphilic carbonaceous conjugates of trypsin and vancomycin, Journal of Materials Chemistry B, 2014, 2, 1681-1688.
24. Yongwei Huang, Junchao Wang, Lina Fu, Wenfeng Kuang, Jiahua Shi*. Effect of Core-substituted Groups on Sensing Properties Based on Single Micro/nanorod of Perylenediimide Derivatives. Sensors and Actuators B: Chemical 2013, 188, 411-416.
25. Jiahua Shi*, Qiang Wu, Runming Li, Yinxu Zhu, Yujun Qin, Congzhen Qiao. pH-Controlled Morphology Transition of Polyaniline from Nanofibers to Nanosphere, Nanotechnology, 2013, 24(17), 175602.
26. Qiang Wu, Chaoqun Liu, Luna Fan, Jiahua Shi*, Huanxia Jia, Qiaofang Qi, Zhiqiang Liu. Heparinized hierarchically hollow hydroxyapatite microspheres as bone substitute: Fabrication and controlled delivery of growth factors, RSC Advances 2013, 3, 7486-7494.
27. Qiang Wu, Chaoqun Liu, Luna Fan, Jiahua Shi*, Zhiqiang Liu, Ruifang Li, Liwei Sun. Heparinized magnetic mesoporous silica nanoparticles as multifunctional growth factor delivery carriers, Nanotechnology, 2012, 23 (48), 485703.
28. Jia-Hua Shi, Bing-Xing Yang, Suat Hong Goh. Covalent functionalization of multiwalled carbon nanotubes with poly(styrene-co-acrylonitrile) by reactive melt blending, European Polymer Journal, 2009, 45 1002-1008.
29. Jia-Hua Shi, Bing-Xing Yang, K. P. Pramoda, Suat Hong Goh. Enhancement of the Mechanical Performance of Poly(vinyl chloride) Using Poly(n-butyl methacrylate)-grafted Multiwalled Carbon Nanotubes, Nanotechnology, 2007, 18, 375704.
30. Jiahua Shi, Zhiyong Chen, Yujun Qin, Zhi-Xin Guo. Multiwalled Carbon Nanotube Microspheres from Layer-by-Layer Assembly and Calcination, J. Phys. Chem. C, 2008, 112, 11617-11622.
31. Jiahua Shi, Yujun Qin, Zhi-Xin Guo, Daoben Zhu. Covalently attached multilayer Self-Assemblies of Single-Walled Carbon Nanotubols and Diazoresins, Nanotechnology, 2007, 18, 365704.
32. Jiahua Shi, Zhi-Xin Guo, Bohan Zhan, Yongfang Li, Daoben Zhu. Actuators Based on PVA/MWNT Hydrogels, J. Phys. Chem. B, 2005, 109, 14789-14791.
33. Jiahua Shi, Yujun Qin, Wei Wu, Xianglong Li, Zhi-Xin Guo, Daoben Zhu. In situ Synthesis of CdS Nanoparticles on Multi-walled Carbon Nanotubes, Carbon, 2004, 42, 465-468.
34. Jiahua Shi, Xun Sun, Chunhe Yang, Qingyu Gao, Yongfang Li. Electrochemical Synthesis of Polythiophene in an Ionic Liquid, Chinese Chemical Letters, 2002, 13, 306-307.
授权专利
1. 一种石墨烯改性聚甲醛复合材料的制备方法，授权号：ZL 201410137947.7
2. 一种棒状杂化纳米材料、含其的药物及其制备方法，授权号：ZL 202010144910.1
3. 特异性卟啉自运输纳米载体材料及其制备方法，授权号：ZL 202011109685.5
参编专著、教材
1.十五国家重点图书《功能材料化学进展》第五章《碳纳米管的化学修饰》，化学工业出版社，2005.08
获得奖励及荣誉
1. 2009年河南省高校青年骨干教师
2. 2010年河南省教育厅学术技术带头人
3. 2011年河南省学术技术带头人
4. 2020年河南省高层次（C类）人才
