陈亮
博士，副教授，硕士生导师
邮箱：liang88chen@henu.edu.cn
个人简介
河南省药理学会理事。主要从事肿瘤药理学和肿瘤靶向治疗研究，研究兴趣集中在食管鳞癌生长、转移和耐药的调控机制及干预策略。在Molecular Cancer、British Journal of Pharmacology和Cell Death & Disease等专业杂志上发表SCI论文多篇。主持国家自然科学基金、中国博士后科学基金、河南省重点研发与推广专项（科技攻关），河南省高等学校重点科研基金及河南省博士后科研基金等项目。指导完成大学生创新创业训练计划项目2项（其中1项被评为国家级项目，另1项被评为省级项目）。先后荣获河南省科技进步奖、河南省科技成果奖及开封市自然科学优秀学术成果奖等荣誉。
代表性论文如下(*为通讯作者)：
1. Huiru Yang, Zhen Wei, Yifan Song, Kexin Du, Nannan Yin, Hong Lu, Bingbing Li, Lili Hou, Panfei Xing, Liang Chen*, Chaojie Wang* and Songqiang Xie*. NUAK1 promotes tumor metastasis through upregulating slug transcription in esophageal squamous cell carcinoma. Cancer Cell International, 2023; 23 (1): 258.
2. Lu Yu, Mingli Xie, Min Chen, Huizu Yang, Liang Chen, Panfei Xing*, Zhiyong Tian*, Chaojie Wang*. An ortho-activation strategy to develop NIR fluorescent probe for rapid imaging of biothiols in vivo. Talanta, 2024; 266(Pt 2):125110.
3. Huishan Zeng; Huiru Yang; Yifan Song; Dong Fang; Liang Chen*; Zhijun Zhao; Chaojie Wang*; Songqiang Xie*. Transcriptional inhibition by CDK7/9 inhibitor SNS-032 suppresses tumor growth and metastasis in esophageal squamous cell carcinoma. Cell Death & Disease, 2021; 12(11): 1048.
4. Chen Liang; Bi Shuning; Wei Qiuren; Zhao Zhijun*; Wang Chaojie*; Xie Songqiang*; Ivermectin suppresses tumor growth and metastasis through degradation of PAK1 in esophageal squamous cell carcinoma. Journal of Cellular and Molecular Medicine, 2020, 24(9):5387-5401.
5. Chen Liang*; Wei Qiuren; Bi Shuning; Xie Songqiang*; Maternal embryonic leucine zipper kinase promotes tumor growth and metastasis via stimulating FOXM1 signaling in esophageal squamous cell carcinoma. Frontiers in Oncology, 2020, 10:10.
6. Bi Shuning; Wei Qiuren; Zhao Zhijun; Chen Liang*; Wang Chaojie*; Xie Songqiang*; Wee1 inhibitor AZD1775 effectively inhibits the malignant phenotypes of esophageal squamous cell carcinoma in vitro and in vivo. Frontiers in Pharmacology, 2019, 10:864.
7. Chen Liang; Bi Shuning; Hou Jiuzhou; Zhao Zhijun*; Wang Chaojie*; Xie Songqiang*; Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells. Cell Communication and Signaling, 2019, 17(1):31.
8. Chen Liang; Pan Jingxuan; Dual cyclin-dependent kinase 4/6 inhibition by PD-0332991 induces apoptosis and senescence in oesophageal squamous cell carcinoma cells. British Journal of Pharmacology, 2017, 174 (15): 2427-2443.
