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王超杰
2017-05-18 17:32   审核人:

河南大学特聘教授,博士生导师,河南省天然产物与免疫工程重点实验室主任,1965年生,1981-1988年在南开大学化学系学习并获得学士和硕士学位,1994-1997在中山大学化学系学习并获得博士学位,曾在日本、美国进修;1988年起一直在河南大学工作,河南大学学术委员会和学位委员会委员,河南省化学会常务理事,副秘书长,“精细化工中间体”、“化学研究”、“河南大学学报(自然版)”编委。河南省高校创新人才培养对象,河南省学术技术带头人,河南省优秀教师,“内源性生物活性分子研究”河南省创新型科技团队牵头人,河南省科技创新杰出青年基金和河南省科技创新杰出人才基金获得者。主要从事有机化学和药物化学方面的教学和科研工作,主持完成国家重大研究计划(培育项目)1项、国家自然科学基金面上项目3项,其它课题多项,在J.Med.Chem.等国内外学术期刊发表论文70余篇,获授权国家发明专利7项。


论文

1. Fujun Dai, Qian Li, Yuxia Wang,* Chaochao Ge, Chenyang Feng, Songqiang Xie,* Haoying He, Xiaojuan Xu, Chaojie Wang*. Design, Synthesis and Biological Evaluation of Mitochondria-Targeted Flavone-naphthalimide-polyamine Conjugates with Antimetastatic Activity.J Med Chem.2017, 60 (5): 2071-2083

2. Wang Yuxia, Zhang Jianying, Li Meng, Li Ming, Xie Songqiang*, Wang Chaojie*.Synthesis and evaluation of novel amonafide-polyamine conjugates as anticancer agents.Chem Biol Drug Des.2017,89:670–680

3.Wang C,Ruan P,Zhao Y,Li X,Wang J,Wu X,Liu T,Wang S,Hou J,Li W,Li Q,Li J,Dai F,Fang D*,Wang C*,Xie S*.Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/β-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.Oncotarget.2017,1,1092-1109

4.Zhiyong Tian, Luyao Zhao, Huanyang Dong, Yan Zhang, Yijuan Zhang, Qianlei Ren, Shuangyu Shao,Yingying Huang,Lina Song, Tao Guo , Xuejun Xu,*, Chaojie Wang*.Study on the interaction of anthracenyl-methyl homospermidineconjugate (ANTMHspd) with DNA by spectroscopic methods.J Photochem Photobiol B.2017,169:27-34

5. Yuan Zhao, Nanhao Chen, Chaojie Wang,* and Zexing Cao*.A Comprehensive Understanding of Enzymatic Catalysis by Hydroxynitrile Lyases with S Stereoselectivity from the α/β-Hydrolase Superfamily: Revised Role of the Active-Site Lysine and Kinetic Behavior of Substrate Delivery and Sequential Product Release.ACS Catalysis.2016, 6, 2145-2157

6. Zhiyong Tian, Yingying Huang, Yan Zhang , Lina Song , Yan Qiao , Xuejun Xu* , Chaojie Wang* Spectroscopic and molecular modeling methods to study the interaction between naphthalimide- polyamine conjugates and DNA.J Photochem Photobiol B.2016,158:1-15

7. Wen Luo*, Ying Chen, Ting Wang, Chen Hong, Li-Ping Chang, Cong-Cong Chang,Ya-Cheng Yang, Song-Qiang Xie , Chao-Jie Wang* Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities. Bioorg. Med. Chem.2016,24,672–680.

8. Wen Luo, Ting Wang, Chen Hong, YaeChen Yang , Ying Chen, Juan Cen*, SongQiang Xie, ChaoJie Wang* Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents.Eur. J Med.Chem.2016, 122, 17-26

9. Qian Li, Yangyang Zhai , Wen Luo, * , Zixin Zhu , Xin Zhang , Songqiang Xie* ,Chen Hong , Yuxia Wang, Yabin Su, Jin Zhao, Chaojie Wang. Synthesis and biological properties of polyamine modified flavonoids as hepatocellular carcinoma inhibitors.Eur. J Med Chem..2016, 121, 110-119

10. Tian Z, Zang F, Luo W, Zhao Z, Wang Y, Xu X*, Wang C* .Spectroscopic study on the interaction between mononaphthalimide spermidine (MINS) and bovine serum albumin (BSA).J Photochem Photobiol B.2015, 142:103-9.

11.Tian ZY, Song LN, Zhao Y, Zang FL, Zhao ZH, Chen NH, Xu XJ*, Wang CJ*.Spectroscopic Study on the Interaction between Naphthalimide-Polyamine Conjugates and Bovine Serum Albumin (BSA). Molecules.2015, 20, 16491-16523

12.Xin Zhang, Jiang Wang, Chen Hong, Wen Luo*,Chaojie Wang*, Design, synthesis and evaluation of genistein polyamine conjugates as multi-functional anti-Alzheimer agents,Acta Pharm. Sinica B,2015,22,67

13Chen L, Kang QH, Chen Y, Zhang YH, Li Q, Xie SQ*, Wang CJ*.Distinct roles of Akt1 in regulating proliferation, migration and invasion in HepG2 and HCT 116 cells. Oncol Rep.2014,31(2):737-44.

14. Mei-Xia Zhao,* Er-Zao Zeng, Yang Li and Chao-Jie Wang*.A study on effects of naphthalimide derivative-capped quantum dots on the cellular internalization, proliferation, and apoptosis ability.J. Mater. Chem. B,2014,2, 7351–7359

15. Tian ZY, Li JH, Li Q, Zang FL, Zhao ZH, Wang CJ.Study on the synthesis, biological activity and spectroscopy of naphthalimide-diamine conjugates.Molecules.2014;19(6):7646-68

16. Mei-Xia Zhao,* Yang Li, Er-Zao Zeng, and Chao-Jie Wang*.The Application of CdSe Quantum Dots with Multicolor Emission as Fluorescent Probes for Cell Labeling.Chem. Asian J.2014, 9, 1349–1355 (封底文章)

17. Chen Hong, Wen Luo*, Dong Yao, Ya-Bin Su, Xin Zhang, Run-Guo Tian, Chao-Jie Wang*. Novel aromatic–polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase. Bioorg. Med. Chem.2014, 22,3213–3219

18. Zhiyong Tian*, Zhonghua Zhao, Fenglei Zang, Yueqiao Wang, Chaojie Wang*. Spectroscopic study on the interaction between naphthalimide–polyamine conjugates and DNA.

J Photochem Photobiol B.2014,138,202–210

19. Kuo-xi Xu∗,Shu-yan Jiao,Wen-yong Yao, Hua-jie Kong, Jing-lai Zhang, Chao-jie Wang∗.Syntheses and highly enantioselective fluorescent recognition of hydroxyl/amino carboxylic acid anions in protic solutions.Sensors and Actuators Bchemical.2013,177,384– 389

20. Wen Luo*, Ya-Bin Su, Chen Hong, Run-Guo Tian, Lei-Peng Su, Yue-Qiao Wang, Yang Li,

Jun-Jie Yue, Chao-Jie Wang*. Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents. Bioorg. Med. Chem.2013, 21, 7275–7282

21.Chen L, Li M, Li Q, Wang CJ*, and Xie SQ*. DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway.Mol. Cancer,2013,12, 157

22. Li M, Li Q, Zhang YH, Tian ZY, Ma HX, Zhao J, Xie SQ*, Wang CJ*. Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro. Anticancer Drugs.2013,24(1):32-42,

23. Wang YX, Zhang XB, Zhao J, Xie SQ*, Wang CJ*. Nonhematotoxic Naphthalene Diimide Modified by Polyamine: Synthesis and Biological Evaluation. J.Med.Chem.2012,55(7), 3502-3512

24. Xie SQ, Zhang YH, Li Q, Xu, FH Miao JW, Zhao J, Wang. CJ*.3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway. Apoptosis,2012,17:725–734

25.Wang JH,Gao RH,Li Q,Xie SQ,Zhao J*,Wang CJ* . Synthesis, cytotoxicity, and cell death profile of polyaminoanthraquinones as antitumor agents.Chem Biol Drug Des.2012,80(6):909-17

26. Xie SQ,Li Q,Zhang YH,Wang JH,Jin Zhao J,Wang CJ*. NPC-16, a novel naphthalimide –polyamine conjugate, inducedapoptosis and autophagy in human hepatoma HepG2 cellsand Bel-7402 cells. Apoptosis,2011,16,27-34 3.59

27. Yang LH, Li W,Tian ZY, Zhao J*, Wang CJ*. Mononaphthalimide spermidine conjugate induces cell proliferation inhibition and apoptosis in HeLa cellsToxicology in Vitro2011,25,882-889

28. Yang LH, Zhao J*, Zhu YQ, Tian ZY, Wang CJ*. Reactive oxygen species (ROS) accumulation induced by mononaphthalimide-spermidine leads to intrinsic and AIF-mediated apoptosis in HeLa cells.Oncology Reports.2011,25,1099-1107

29. Wang JH, Zhou JJ, Xie SQ, Li Q, Zhao J*, Wang CJ*. Synthesis andbioevalution of hydrazine- containing polyamine skeletons as drug delivery system.Chin. Chem. Lett.2011,22, 119-122

30. Kuo-xi Xu, Peng-fei Cheng, Jin Zhao, Chao-jie Wang* Enantioselective Fluorescent Sensors for Amino Acid Derivatives based on BINOL Bearing S-Triphtophan Unit: Synthesis and chiral recognition.J.Fluoresc.2011, 21,991-1000

31. Xie, S.-Q., Wang, J.-H., Zhang, Y.-H, Wang, C.-J*.Antitumor conjugates with polyamine vectors and their molecular mechanisms.Expert Opinion on Drug Delivery,2010, 7(9), 1049-61(invited review)

32. Wang, J.; Chen, Z.; Songqiang, X.; Zhao, J.; Wang, CJ*.Synthesis and bioevaluation of aryl-guanidino polyamine conjugates targeting the polyamine transporter. Bioorg. & Med. Chem. Lett.2010,20, 6421–6425.

33.Kuo-xi Xu, Yu-xia Wang, Shu-yan Jiao, Jin Zhao, and Chao-jie Wang*.Enantioselective fluorescent sensors for chiral carboxylates based on BINOL — Synthesis and chiral recognition.Can. J. Chem. 2010, 88(4): 367–374

34. Xu KX, Bu ZW, Zhao J,Wang CJ*.Enantioselective Fluorescent Sensors for N-Boc-Protected Amino Acid Anions Based on BINOL,Chin.J. Chem.2010,28, 803-810

35.Kuo-xi Xu,Yang LR, Wang YX, Zhao J,Wang CJ*.Synthesis and enantioselective fluorescent sensors for amino acid derivatives based on BINOL.Supramolecular Chemistry,2010,22, 563-570.

36.Zhi-yong Tian, Song-qiang Xie, Zi-hou Mei, Jin Zhao, Wen-yuan Gao* and Chao-jie Wang*Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal Pathway Organic & Biomolecular Chemistry2009,7, 4651–4660 (Highlights in Chemical Biology: Research Articles, issue 12, 2009

37.Xie, SQ., Wang, JH., Ma, HX., Cheng, PF.Zhao, J., Wang, CJ*.Polyamine transporter recognization and antitumor effects of anthracenymethyl homospermidine,Toxicology,2009, 263, 127-133

38. Zhiyong Tian ,Songqiang Xie, Yaowu Du , Yuanfang Ma , Jin Zhao , Wenyuan Gao*, Chaojie Wang*.Synthesis, cytotoxicity and apoptosis of naphthalimide polyamine conjugates as antitumor agents.Eur. J. Med. Chem.2009,44, 393-399

39. Kuo-xi Xu, Zhen Qiu, Jin-Jin Zhao, Jin Zhao, Chao-jie Wang*.Enantioselective fluorescent sensors for amino acid derivatives based on BINOL bearing benzoyl unit.Tetrahedron:Asymmetry.2009, 20, 1690-1696

40. Kuo-Xi Xu, Peng-Fei Chen, Yu-Xia Wang, Jin Zhao and Chao-Jie Wang*.Enantioselective fluorescent recognition of mandelate by substituted BINOL in aqueous solutions.SupramolecularChemistry.2009,21(7),618-624

41.梅子厚,田智勇,马红霞,谢松强,赵瑾,王超杰

萘酰亚胺-多胺缀合物的合成及抗肿瘤活性研究药学学报2009,44,754-757

42. Jianhong Wang, Songqiang Xie, Yanjie Li, Yongjun Guo, Yuanfang Ma, Jin Zhao, Chaojie Wang*. Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents Bioorganic & Medicinal Chemistry.2008, 16, 7005-7012

43. Songqiang Xie,Guangchao Liu, Yuanfang Ma , Pengfei Cheng, Yingliang Wu, Minwei Wang, Bian sheng Ji, Jin Zhao, Chao-jie Wang*. Synergistic antitumor effects of anthracenylmethyl homospermidine and alpha-difluoromethylornithine on promyelocyticleukemia HL60 cells Toxicology in Vitro.2008,22,352–358

44. Zhi Yong Tian, Hong Xia Ma, Song Qiang Xie, Xue Wang, Jin Zhao, Chao Jie Wang*,Wen Yuan Gao*.Synthesis, DNA binding and topoisomerase inhibition of mononaphthalimide homospermidine derivatives.Chin. Chem. Lett., 2008, 19, 509-512

45. Jun Jun Zhou, Hao Huang, Song Qiang Xie,Yu Xia Wang, Jin Zhao, Chao Jie Wang*.Synthesis and molecular recognization of polyamine transporter of hydrazine modified diamine conjugates Chin.Chem. Lett.2008. 19,(1), 99-101

46.赵瑾,刘洋,郑梅花,谢松强,王超杰. 8-取代黄酮类衍生物的合成及生理活性研究,有机化学2008,1, 84-88

47. Songqiang Xie, Pengfei Cheng, Guangchao Liu, Yuangfang Ma, Jin Zhao, Mounir Chehtane, Annette R. Khaled, Otto Phanstiel IV and Chaojie Wang*. Synthesis and Bioevaluation of the N-(Arylalkyl)-Homospermidine Conjugates.Bioorg.Med.Chem.Lett.2007, 17, 4471-4475

48. Song-qiang XIE, Ying-liang WU, Peng-fei CHENG, Min-wei WANG, Guang-chao LIU, Yuan-fang MA, Jin ZHAO, Chao Jie WANG*. A novel homospermidine conjugate inhibits growth and induces apoptosis in human hepatoma cells.Acta Pharmacol Sin.2007, 11,1827-1834

49. Peng Fei CHENG, Jian Hong WANG, Song Qiang XIE, Jin ZHAO, Chao Jie WANG*. The Synthesis and Bioevaluation of the Dicyclic Arene-Homospermidine Conjugates,Chin. Chem. Lett.2007, 18,923-925

50. ZhiYong Tian, GangJun Du, SongQiang Xie, Jin Zhao, WenYuan Gao*,ChaoJie Wang*.Synthesis and Bioevaluation of 5-Fluorouracil Derivatives.Molecules.2007, 12, 2450-2457

51.赵瑾,赵永梅,罗稳,谢松强,王超杰.苯甲酸氮芥衍生物的合成及抑瘤活性.药学学报2007,,12, 1327-1329

52.王建红,程鹏飞,孙心齐,赵瑾,王超杰. N-(茄呢基哌嗪烷基)蒽甲胺的合成及其与DNA作用的研究.光谱学与光谱分析,2007, 27 : 1398-1402.

53.谢松强,吴英良,程鹏飞,王敏伟,刘广超,赵瑾,王超杰.新型多胺缀合物NNAMB诱导B16细胞凋亡及分化作用.中国药理学通报2007,23,1285-1290

54.Wang Chaojie, Wang Jianhong, Gan Ying , Chen Zhiyong, Du Gangjun, Zhao Jin. Synthesis and Antitumor Activities InVitro of Solanesylpiperazinotriamine.Chin.Chem.Lett.,2006, 17 (10): 1301-1304.

55.王玉霞,赵瑾,孙心齐,王超杰.N-哌嗪烷基酰胺类化合物的合成与DNA相互作用及生理活性.有机化学 2006,8,1066-72

56. Richard Andrew Gardner, Rebecca Kinkade, Chaojie Wang, Otto Phanstiel IV*. Total Synthesis of Petrobactin and its Homologues as potential Growth Stimuli for Marino bacter Hydrocarbonoclasticus, an Oil-degrading Bacteria.J. Org .Chem.2004, 69, 3530-3537

57. Chaojie Wang, Jean-Guy Delcros, Laura Cannon, Fanta Konate, Horacio Carias, John Biggerstaff, Richard Andrew Gardner, and Otto Phanstiel IV*. Defining the Molecular Requirements for the Selective Delivery of Polyamine Conjugates into Cells Containing Active Polyamine Transporters.J.Med.Chem.2003,46,5129 - 5138

58.Chaojie Wang, Jean-Guy Delcros, John Biggerstaff, Otto Phanstiel IV*. Molecular Requirements for Targeting the Polyamine Transport System. Synthesis and Biological Evaluation of Polyamine-Anthracene Conjugates.J.Med.Chem.2003, 46, 2672-2682

59. Chaojie Wang, Jean-Guy Delcros, John Biggerstaff, Otto Phanstiel IV*. Synthesis and Biological Evaluation of N1- (anthracen-9-ylmethyl)triamines as Molecular Recognition Elements for the Polyamine Transporter.J.Med.Chem.2003, 46, 2663-71

60. Chaojie Wang; Khalil A. Abboud; Otto Phanstiel IV*. The Synthesis and Characterization of N1-(4-toluenesulfonyl)-N1-(9-anthracenemethyl) triamines.J.Org.Chem.2002,67,7865-7868


专利:

1.王超杰,罗稳,姚东,赵咏梅,含芳环结构的多胺衍生物及其制备方法和应用,ZL201210591736.1 授权2015.11.18

2. 王超杰,罗稳,李骞,朱子新,翟洋洋, 含黄酮结构的多胺衍生物及其制备方法和应用, ZL201310340647.4 授权2015.08.12

3. 赵美霞,王超杰,李洋,一种萘酰亚胺-氨基酸化合物及其修饰的量子点的制备、应用,

ZL 2013 1 0691278.3 授权 2015.05.13

4. 王超杰,甘莹,赵瑾,姬汴生,一种多胺衍生物及其制备方法和应用,ZL 201010152866.6 2012.05授权

5. 王超杰,王建红,赵瑾,甘莹,茄呢醇多胺衍生物、制备及其应用, ZL 200710054080.9

2010.09授权

6.王超杰,田智勇,赵瑾,谢松强,一种含萘酰亚胺结构的多胺衍生物及其制备方法和应用,ZL200810049299.4,2012.09授权

7.王超杰,王建红,赵瑾,甘莹,一种天然多胺的衍生物、制备及其应用 ZL200710054236.3 2009.09授权

8.王超杰,王玉霞,代付军,谢松强,李骞。一类苯并吡喃-4-酮取代的“萘酰亚胺-多胺”缀生物及其制备方法和用途。申请号:201610101385X


奖励:

1.王超杰,谢松强,王建红,田智勇,程鹏飞,李骞,赵瑾.靶向性多胺缀合物抗肿瘤作用及机制研究。河南省人民政府,河南省科技进步奖,三等奖,2013年.

2.赵瑾,王超杰,王建红,甘莹,王玉霞,刘洋,谢松强,闫琳.茄尼醇结构修饰物用于药物开发的基础研究。河南省人民政府,河南省科技进步奖,二等奖,2010年.


课题:

1.基于多胺循环的“类黄酮-多胺”缀合物合成与抗肿瘤活性研究. 21172053.国家自然科学基金,2012/01-2015/12,65万,结题,主持

2.基于多胺转运的萘酰亚胺类小分子化合物对肿瘤细胞凋亡信号通路的影响,90913001,“基于化学小分子探针的信号转导过程研究”国家重大研究计划培育项目,2010/01-2012/12,50万,结题,主持

3.双重靶向性“蒽醌-多胺”缀合物的合成与生物活性,20872027,国家自然科学基金,2009/01-2011/12,26万,结题,主持

4.以多胺为靶向载体的给药系统的合成与构效研究,20472016,国家自然科学基金,2005/01-2007/12,23万,结题,主持

5.基于萘酰亚胺的PARP-1抑制剂合成及抗肿瘤活性研究,134200510009,河南省科技创新杰出人才基金,50万,2013/01-2015/12,结题,主持

6.“线性多胺-药物” 靶向给药体系的合成与构效关系研究,512001300,河南省科技创新杰出青年基金,16万,2005/01-2007/12,结题,主持

7、多胺化合物的抗肿瘤研究,豫教高〔2004〕239号,河南省高校创新人才培养对象,30万,2005/01-2009/12,结题,主持

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